DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and TAAR5

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001376456.1	Gene:	TAAR5 / 9038	HGNCID:	30236	Length:	337	Species:	Homo sapiens

Alignment Length:	350	Identity:	90/350 - (25%)
Similarity:	151/350 - (43%)	Gaps:	72/350 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LNIPYTVFEVLVA--IVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILAS 102
            |.|...::....|  ::.::|||.|.......:.|...||:.::|||:||:.:|.|.:|.:.:
Human    31 LGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFKALHTPTNFLLLSLALADMFLGLLVLPLSTI-- 93

  Fly   103 MGLPRNLHACLFTVSLL--------VVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFI 159
                |::.:|.|....|        .:.|..|||.|..:|:||:.||..|:.|......|.|:..
Human    94 ----RSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRY 154

  Fly   160 ISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMD---------YNYLVFLYFATIITPALLML 215
            |...|  |....:..|| .:.||...:...::|.|.         ..:..:|.|.....|.|:|:
Human   155 ILAGW--GVPAAYTSLF-LYTDVVETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMI 216

  Fly   216 AFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQ 280
            :.|..|:.|..:|.:||.|::                             :.|..|.|.:.||.:
Human   217 SLYVKIFVVATRQAQQITTLS-----------------------------KSLAGAAKHERKAAK 252

  Fly   281 NLSIIVLFFMICWIPLYTINCIKAFCPDCYVH---PKLTLFCII-LSHLNSAVNPVLYAYHLKDF 341
            .|.|.|..:::||:| :||:.:    .|..:|   |.|.....| .::.|||.||::|.:..:.|
Human   253 TLGIAVGIYLLCWLP-FTIDTM----VDSLLHFITPPLVFDIFIWFAYFNSACNPIIYVFSYQWF 312

  Fly   342 RAALKNLLLKMM------GVDIDQQ 360
            |.|||..|.:.:      .||:.|:
Human   313 RKALKLTLSQKVFSPQTRTVDLYQE 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	49/186 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	77/296 (26%)
TAAR5	NP_001376456.1	7tmA_TAAR5	35..316	CDD:320441	81/323 (25%)
		TM helix 1	37..61	CDD:320441	5/23 (22%)
		TM helix 2	70..92	CDD:320441	9/21 (43%)
		TM helix 3	108..130	CDD:320441	5/21 (24%)
		TM helix 4	153..169	CDD:320441	3/17 (18%)
		TM helix 5	197..220	CDD:320441	5/22 (23%)
		TM helix 6	251..273	CDD:320441	8/22 (36%)
		TM helix 7	284..309	CDD:320441	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910