DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and KISS1R

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_115940.2	Gene:	KISS1R / 84634	HGNCID:	4510	Length:	398	Species:	Homo sapiens

Alignment Length:	338	Identity:	85/338 - (25%)
Similarity:	139/338 - (41%)	Gaps:	46/338 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DAKDSDSPSSELNIPYTV--FEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVG 91
            :|.|...||......:.|  |...:.::.::||.|||.|..|.:.:|..||:||.:||..|:...
Human    28 NASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFL 92

  Fly    92 ALGIPF-AILASM-GLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTR 154
            ...:|| |:|..: |.......|.|...:..|....:...|.|:||||::..::|:........|
Human    93 LCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPR 157

  Fly   155 TAIFIISMCWVAGTIVGFLPLFGWH----ADVNHNQECLFVEVMDYNYLVFLYFATIITPALLML 215
            .|:.:....||....|. .|:...|    ....:..|......::..:.::...|..:.|.|...
Human   158 LALAVSLSIWVGSAAVS-APVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATC 221

  Fly   216 AFYT----HIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDV 276
            |.|.    |:.||.::..       ||      .||...||           :....||.|   .
Human   222 ACYAAMLRHLGRVAVRPA-------PA------DSALQGQV-----------LAERAGAVR---A 259

  Fly   277 KATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPK------LTLFCIILSHLNSAVNPVLYA 335
            |.::.::.:||.|..||.|:.....::|..|....||:      |..:...:|:.|||:||:|||
Human   260 KVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYA 324

  Fly   336 YHLKDFRAALKNL 348
            :....||.|.:.:
Human   325 FLGSHFRQAFRRV 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	43/177 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	73/291 (25%)
KISS1R	NP_115940.2	7tm_4	53..>157	CDD:304433	30/103 (29%)
		7tm_1	59..323	CDD:278431	73/291 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..363
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910