DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Ptger4

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_114465.3	Gene:	Ptger4 / 84023	RGDID:	628641	Length:	488	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	120/525 - (22%)
Similarity:	200/525 - (38%)	Gaps:	122/525 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYY--IVSLAMADLLVG 91
            :|..|.:| ..||.|.|:..|:. |..::||::.|:|..:.||.::.|.:|  :..||:.|||..
  Rat     7 NASFSSTP-ERLNSPVTIPAVMF-IFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGT 69

  Fly    92 ALGIPFAILASM--GLPRNLHACLFTVSLLVV--LCTISIFCLVAVSVDRYWAILYPMAYSRNVR 152
            .|..|..|...|  ..|.:...|.::..:|:.  |..:||.|  |:|::||.||.:...||..|.
  Rat    70 LLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIIC--AMSIERYLAINHAYFYSHYVD 132

  Fly   153 TRTAIFIISMCWVAGTIVGFLPLFG----------------WHADVNHNQECLFVEVMDYNYL-- 199
            .|.|...:...:.:..:...||..|                |..:|.      ......|.|.
  Rat   133 KRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVT------AYAAFSYMYAGF 191

  Fly   200 -VFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSS-----------AAVVQV 252
             .||..||::...|:..|        :::..||.:         ||:|           |||..|
  Rat   192 SSFLILATVLCNVLVCGA--------LLRMHRQFM---------RRTSLGTEQHHAAAAAAVASV 239

  Fly   253 TTPGRGGHTGTMLRVLGAARKRDVK--ATQNLSIIVLFF------MICWIPLYTINCIKAFCPDC 309
            ...|....:..:.|:....|:|..:  |...:.:::|..      :||.|||    .::.|....
  Rat   240 ACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPL----VVRVFINQL 300

  Fly   310 YVHPKLT--------LFCIILSHLNSAVNPVLYAYHLKDFRA----ALKNLLLKMMGVDIDQQA- 361
            | .|.:.        |..|.::.:|..::|.:|....|...:    .:|.|..::.|...|..|
  Rat   301 Y-QPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQ 364

  Fly   362 ---EAIHRFSVASQHRLQSMDSNMR----STQPRLYVGEYSPIWLRQQQEALKNSQLLPKCGVVS 419
               |:....|..|.|....:...:|    ::|..||:.:.:       :.:|....|||..
  Rat   365 HCSESRRTSSAMSGHSRSFLSRELREISSTSQTLLYLPDLT-------ESSLGGKNLLPGT---- 418

  Fly   420 PCFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYE--FPSPAPGSQR---SSERNSSS 479
               :.:..|.|...|:.|      ..|.|.|..:: |:.|..  ......||||   :|:.||..
  Rat   419 ---HGMGLTQADTTSLRT------LRISETSDSSQ-GQDSESVLLVDEVSGSQREEPASKGNSLQ 473

  Fly   480 TVPPA 484
            ...|:
  Rat   474 VTFPS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	49/192 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	75/327 (23%)
Ptger4	NP_114465.3	7tmA_PGE2_EP4	18..344	CDD:320270	82/356 (23%)
		TM helix 1	20..44	CDD:320270	8/24 (33%)
		TM helix 2	55..77	CDD:320270	8/21 (38%)
		TM helix 3	93..115	CDD:320270	6/23 (26%)
		TM helix 4	138..154	CDD:320270	0/15 (0%)
		TM helix 5	181..204	CDD:320270	6/22 (27%)
		TM helix 6	274..296	CDD:320270	6/25 (24%)
		TM helix 7	311..336	CDD:320270	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..380		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910