DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and adrb3b

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_021334880.1	Gene:	adrb3b / 792519	ZFINID:	ZDB-GENE-081022-154	Length:	417	Species:	Danio rerio

Alignment Length:	338	Identity:	94/338 - (27%)
Similarity:	153/338 - (45%)	Gaps:	75/338 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGA----LGIPFAILAS--MGLPRN 108
            ||..:::|||:|||:...|...|...||.:|:|:|.|||::|.    ||:...:...  :|.|
Zfish    23 LVIFLTVIGNLLVILAIARTPLLHTTTNVFIISMAFADLIMGCVVQPLGLSMVVAGKWVLGNP-- 85

  Fly   109 LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFL 173
              .|....||.|...|.||..|.|::|:||.||..|:.:...:..|.|.:|:...|:..::|.|:
Zfish    86 --MCDLWTSLDVFCVTASIETLCAIAVERYIAITRPLEHQVLLGKRRAAYIVCTVWIVSSLVSFV 148

  Fly   174 PLFGWHADVNHNQECLFVEVMD-YN------------YLVFLYFATIITPALLMLAFYTHIYRVI 225
            |:      :|||....::...| ||            |.:|....:...|.|:|:..|..::.:.
Zfish   149 PI------MNHNSRANYLAANDCYNNSECCDFHTNQHYAIFSSVVSFYVPLLVMVFLYGKVFAIA 207

  Fly   226 IKQVRQI-----------------VTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARK 273
            .||::.|                 :....|...|||::..||
Zfish   208 NKQLKLIGKDRLRFLSSCNEDSCEIPEGSARSYSRRTTKHVV----------------------- 249

  Fly   274 RDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCII--LSHLNSAVNPVLYAY 336
            ::.||.:.|.||:..|.:||:|.:..|.||:|.|:.   |...:|.::  |.:.||.:||::|.
Zfish   250 KEHKALKTLGIIMGIFSLCWLPFFIFNIIKSFNPEV---PTQLVFLLLNWLGYANSGLNPIIYC- 310

  Fly   337 HLKDFRAALKNLL 349
            |..::|.|..|||
Zfish   311 HSPEYRNAFFNLL 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	55/186 (30%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	84/313 (27%)
adrb3b	XP_021334880.1	7tmA_Beta_AR	25..319	CDD:320186	88/330 (27%)
		TM helix 2	49..76	CDD:320186	11/26 (42%)
		TM helix 3	87..117	CDD:320186	13/29 (45%)
		TM helix 4	131..149	CDD:320186	5/17 (29%)
		TM helix 5	177..209	CDD:320186	6/31 (19%)
		TM helix 6	249..279	CDD:320186	11/52 (21%)
		TM helix 7	288..313	CDD:320186	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910