DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and s1pr1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001072893.1	Gene:	s1pr1 / 780355	XenbaseID:	XB-GENE-977003	Length:	374	Species:	Xenopus tropicalis

Alignment Length:	383	Identity:	93/383 - (24%)
Similarity:	162/383 - (42%)	Gaps:	63/383 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPR 107
            |.::..:::....::.|:||::...|.:|..|...|:|.:||::|||.|.     |..|::.|..
Frog    39 PTSIIFIIICCFIVLENILVLLTIWRTKKFHRPMYYFIGNLALSDLLAGT-----AYTANILLSG 98

  Fly   108 NLHACLFTVSLLV------VLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVA 166
            .....|..|..|:      |..:.|:|.|||::::||..:| .|......::..:..:||.||:.
Frog    99 PHTYKLTPVEWLIREGSMFVALSASVFSLVAIAIERYITML-KMKLHNGSKSSRSFLLISGCWIL 162

  Fly   167 GTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLM--LAFYTHIYRVIIKQV 229
            ...:|.||:.||:. :.....|..|..:.:.:  ::.|.|.|..||||  :..|..||.::..:.
Frog   163 SLFLGGLPIMGWNC-IKQISACSTVLPLYHKH--YILFCTTIFCALLMAIVILYARIYFLVRTRS 224

  Fly   230 RQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWI 294
            |.:......:..||.|..::..:.|                           :.|::..|::||.
Frog   225 RSLTFKRNLARPSRSSEKSMALLKT---------------------------VIIVLSVFILCWS 262

  Fly   295 PLY-----TINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKM-- 352
            ||:     ...|....||..:   |...| :.|:.||||.||::|....::.|.|    .|||
Frog   263 PLFIFLLLDFGCKVKTCPVLF---KAEYF-LSLAVLNSATNPIIYTLTNREMRRA----FLKMAC 319

  Fly   353 -MGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQEALKNS 409
             ....|...:..:.|..:......:|...|  |:.|:...||| |:.|........:|
Frog   320 CSHCSIFGSSSKVKRPIITGMEFSRSKSDN--SSHPQKDEGEY-PVTLMSSGNVTSSS 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	49/175 (28%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	74/288 (26%)
s1pr1	NP_001072893.1	7tmA_S1PR1_Edg1	38..314	CDD:320468	78/318 (25%)
		TM helix 1	39..65	CDD:320468	4/25 (16%)
		TM helix 2	72..97	CDD:320468	10/29 (34%)
		TM helix 3	109..139	CDD:320468	9/29 (31%)
		TM helix 4	150..170	CDD:320468	5/19 (26%)
		TM helix 5	190..219	CDD:320468	10/30 (33%)
		TM helix 6	241..271	CDD:320468	7/56 (13%)
		TM helix 7	282..307	CDD:320468	10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910