DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and gpr83

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001072505.1	Gene:	gpr83 / 779960	XenbaseID:	XB-GENE-5817068	Length:	420	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	89/395 - (22%)
Similarity:	157/395 - (39%)	Gaps:	111/395 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DAK-DSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGA 92
            |.| :::|.||.:.....|...::.::|:.||:||..|..:..:::..|:.:||:||:||:::..
Frog    56 DTKYEAESQSSTVKALLIVAYSVIIVISLFGNILVCHVVIKNSRMQSATSLFIVNLAVADIMITL 120

  Fly    93 LGIPFAILASMGLPRNLHACLFTVSLLVVLCT--ISIFCLVAVSVDRYWAILYPMAYSRNVRTRT 155
            |..||.::..:.........:..||..|..|:  :|:..|:|:::||:..|::|:  ...:.|..
Frog   121 LNTPFTLVRFVSSTWVFGKLMCHVSRFVQYCSVHVSVLTLMAIALDRHQVIMHPL--KPRMSTVK 183

  Fly   156 AIFIISMCWVAGTIVGF-----------------------LPLFGWHADVNHNQECLFVEVMDYN 197
            .|..|.:.|...:  ||                       ||.|.:.||       ||.:.:|..
Frog   184 GIICIIVIWFMAS--GFSLPHAVYQKLEQFFIGNTVRMVCLPSFPYPAD-------LFWKYLDLA 239

  Fly   198 YLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTG 262
            ..|.||    :.|.:::...||.:       .:::...|...|:
Frog   240 TFVLLY----VLPLIVISITYTTV-------AKKLWLRNAIGDI--------------------- 272

  Fly   263 TMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNS 327
            ||.:.....||:.: ..:.|.::|:.|.:||.||           :||    |.|....:...|:
Frog   273 TMEQYYAHRRKKKM-TLKMLMLVVVVFAVCWFPL-----------NCY----LVLMSSKVISSNN 321

  Fly   328 AV--------------NPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSM 378
            |:              ||.:|.:..:.||:.||.||.            ...|.|.|..|.|||:
Frog   322 AIYFAFHWFAMSSTCYNPFIYCWLNESFRSELKALLC------------VCRRRSPAQSHPLQSV 374

  Fly   379 DSNMR 383
            ....|
Frog   375 SPQFR 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/192 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/314 (21%)
gpr83	NP_001072505.1	7tmA_GPR83	70..353	CDD:320511	72/341 (21%)
		TM helix 1	71..97	CDD:320511	7/25 (28%)
		TM helix 2	104..129	CDD:320511	10/24 (42%)
		TM helix 3	142..172	CDD:320511	9/29 (31%)
		TM helix 4	183..204	CDD:320511	5/22 (23%)
		TM helix 5	233..262	CDD:320511	7/39 (18%)
		TM helix 6	282..312	CDD:320511	12/45 (27%)
		TM helix 7	321..346	CDD:320511	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910