DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and TRHR

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_003292.1	Gene:	TRHR / 7201	HGNCID:	12299	Length:	398	Species:	Homo sapiens

Alignment Length:	351	Identity:	89/351 - (25%)
Similarity:	150/351 - (42%)	Gaps:	70/351 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSSELNIPYTVFEVLVAIV----SIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIP 96
            |.:.:.:.|.|..:|:.::    .|:||::|::|..|.:.:|..||.|:||||:|||:|
Human    16 PRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMV------ 74

  Fly    97 FAILASMGLPR-----------NLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPM----- 145
               |.:.|||.           ....||....|..:....|...:.|.:::||.||.:|:
Human    75 ---LVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFL 136

  Fly   146 -AYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEV---MDYNYLVFLYFAT 206
             .:||      |..||...|...::...|..|....:::..::.:.:..   :..||...:|...
Human   137 CTFSR------AKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMD 195

  Fly   207 I----ITPALLMLAFYTHIYRVIIKQVRQIVTMNP-ASDLSRRSSAAVVQVTTPGRGGHTGTMLR 266
            .    :.|.:|....|..|.|::.        :|| .||....|.      |......|..|.|.
Human   196 FGVFYVVPMILATVLYGFIARILF--------LNPIPSDPKENSK------TWKNDSTHQNTNLN 246

  Fly   267 V---------LGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIIL 322
            |         ..::||   :.|:.|:::|:.|.:.|:|..|:..:.:|....:......|||.|.
Human   247 VNTSNRCFNSTVSSRK---QVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRIC 308

  Fly   323 SHLNSAVNPVLYAYHLKDFRAALKNL 348
            .:||||:|||:|....:.||||.:.|
Human   309 IYLNSAINPVIYNLMSQKFRAAFRKL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/195 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	78/309 (25%)
TRHR	NP_003292.1	7tmA_TRH-R	26..331	CDD:320126	85/336 (25%)
		TM helix 1	27..53	CDD:320126	6/25 (24%)
		TM helix 2	60..85	CDD:320126	15/33 (45%)
		TM helix 3	98..128	CDD:320126	8/29 (28%)
		TM helix 4	141..162	CDD:320126	6/26 (23%)
		TM helix 5	188..217	CDD:320126	5/28 (18%)
		TM helix 6	259..289	CDD:320126	9/32 (28%)
		TM helix 7	299..324	CDD:320126	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910