DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Gpr173

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001300677.1	Gene:	Gpr173 / 70771	MGIID:	1918021	Length:	373	Species:	Mus musculus

Alignment Length:	375	Identity:	96/375 - (25%)
Similarity:	154/375 - (41%)	Gaps:	75/375 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AATTSKDAKDSDSPSSELNIPYT------VFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIV 81
            |.||.    :.:..|..|::|..      |...|:..||:.||.::.::..:||.|.:...|:::
Mouse     2 ANTTG----EPEEVSGALSLPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLL 62

  Fly    82 SLAMADLLVGALGIPFAILASMGLPRNLHACLFTVSLL---------VVLCTISIFCLVAVSVDR 137
            .|.:||.:..|:..|| :|||:     .|...:|.|.|         |:.|..:.|.|..:||.|
Mouse    63 DLCLADGIRSAICFPF-VLASV-----RHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTR 121

  Fly   138 YWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLF--GWHADVNHNQECLFVEVMDYNY-- 198
            |.||.:...|::.:...|...:|.|.|.....:.|.|:|  |.:..:....:|:|    ::.|
Mouse   122 YMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF----EHRYFK 182

  Fly   199 ----------LVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRR--------- 244
                      |..|..||......|:|..|.|       :..:.|.|.||  :|:.
Mouse   183 ANDTLGFMLMLAVLMAATHAVYGKLLLFEYRH-------RKMKPVQMVPA--ISQNWTFHGPGAT 238

  Fly   245 SSAAVVQVTTPGRGGHTGTML--RVLGAARKR------DVKATQNLS----IIVLFFMICWIPLY 297
            ..||...:...|||....|:|  |..|.|..|      :||..:.|.    .|.|.|::.|.| |
Mouse   239 GQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSP-Y 302

  Fly   298 TINCI-KAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALK 346
            .:.|. :.|...|.|..:.....:.:|...:||||::.....||.:..|:
Mouse   303 IVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLR 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	50/190 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	83/320 (26%)
Gpr173	NP_001300677.1	7tm_GPCRs	23..351	CDD:421689	89/347 (26%)
		TM helix 1	24..50	CDD:410628	6/25 (24%)
		TM helix 2	57..82	CDD:410628	8/25 (32%)
		TM helix 3	96..126	CDD:410628	9/29 (31%)
		TM helix 4	138..160	CDD:410628	6/21 (29%)
		TM helix 5	181..210	CDD:410628	5/28 (18%)
		TM helix 6	279..309	CDD:410628	9/30 (30%)
		TM helix 7	319..344	CDD:410628	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910