DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Gpr85

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001317595.1	Gene:	Gpr85 / 64450	MGIID:	1927851	Length:	370	Species:	Mus musculus

Alignment Length:	345	Identity:	77/345 - (22%)
Similarity:	141/345 - (40%)	Gaps:	43/345 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PYTVFEVLVAI-----VSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPF---AI 99
            |.|.|..|.::     ||::||:|:.|:..:::.|.|...|:::.|..:|:|..|:..||   ::
Mouse    17 PLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSV 81

  Fly   100 LASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCW 164
            ............|.....|.|:.|..:.|.|..:||.||.||.:...|::.:...|.:.:|.|.|
Mouse    82 KNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVW 146

  Fly   165 VAGTIVGFLPLF--GWHADVNHNQECLFVEVM-----DYNYLVFLYFATIITPAL-LMLAFYTHI 221
            .....:.|.|:.  |.::.:....:|.|....     ...:::.|....:.|..: |.|.|:.|.
Mouse   147 TLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLATQLVYLKLIFFVHD 211

  Fly   222 YRVIIKQVRQIVTMN-------PASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAA----RKR- 274
            .|. :|.|:.:..::       |.:.    ..||...:...|||....|:|.:...|    |:|
Mouse   212 RRK-MKPVQFVAAVSQNWTFHGPGAS----GQAAANWLAGFGRGPTPPTLLGIRQNANTTGRRRL 271

  Fly   275 ----DVKATQNLS----IIVLFFMICWIPLYTINCI-KAFCPDCYVHPKLTLFCIILSHLNSAVN 330
                :.|..:.:|    |:...|:..|.| |.:.|. :.|.....|........:.:|...:.:|
Mouse   272 LVLDEFKMEKRISRMFYIMTFLFLTLWGP-YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGIN 335

  Fly   331 PVLYAYHLKDFRAALKNLLL 350
            |.:..:..::.|......||
Mouse   336 PFVCIFSNRELRRCFSTTLL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	42/183 (23%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	68/307 (22%)
Gpr85	NP_001317595.1	7tmA_SREB2_GPR85	21..350	CDD:320346	73/334 (22%)
		TM helix 1	23..47	CDD:320346	7/23 (30%)
		TM helix 2	56..78	CDD:320346	7/21 (33%)
		TM helix 3	95..117	CDD:320346	5/21 (24%)
		TM helix 4	140..156	CDD:320346	4/15 (27%)
		TM helix 5	182..205	CDD:320346	3/22 (14%)
		TM helix 6	284..306	CDD:320346	6/22 (27%)
		TM helix 7	318..343	CDD:320346	3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910