DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and NPFFR1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_071429.1	Gene:	NPFFR1 / 64106	HGNCID:	17425	Length:	430	Species:	Homo sapiens

Alignment Length:	353	Identity:	82/353 - (23%)
Similarity:	155/353 - (43%)	Gaps:	59/353 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PLHAATTSKDAKDSDSPSSELNIP------------YTVFEVLVAIVSIIGNVLVIIVFRRERKL 72
            ||....|:.:|    :|::.|...            :.|...|:.::.::||.||..:..:.|.:
Human    14 PLSQNGTNTEA----TPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHM 74

  Fly    73 RRRTNYYIVSLAMADLLVGALGIPFAILASM--GLPRNLHACLFTVSLLVVLCTISIFCLVAVSV 135
            ...||.:|::||::|||||...:|..::.::  |.|.:...|..:..:..:..:.|:|.|||::|
Human    75 HTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAV 139

  Fly   136 DRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIV---GFLPLFGWHADVNHNQECLFVEVMDYN 197
            :|:..|::|  :...:..|.|:..|::.|....::   ..:.|     .|...:....|:..:.:
Human   140 ERFRCIVHP--FREKLTLRKALVTIAVIWALALLIMCPSAVTL-----TVTREEHHFMVDARNRS 197

  Fly   198 YLVFLYFATIITPALLMLAFYT-----HIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGR 257
            |.  ||......|...|...||     |||   :..:..||.|      ..|.:..:.|...|..
Human   198 YP--LYSCWEAWPEKGMRRVYTTVLFSHIY---LAPLALIVVM------YARIARKLCQAPGPAP 251

  Fly   258 GGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCI----KAFCPDCYVHPKLTLF 318
            ||......|    |.:|..:....|.::.|||.:.|:||:.:..:    :...|..::   :|::
Human   252 GGEEAADPR----ASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHL---VTVY 309

  Fly   319 CIILSH----LNSAVNPVLYAYHLKDFR 342
            ....:|    .||:.||::|.|..::||
Human   310 AFPFAHWLAFFNSSANPIIYGYFNENFR 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	42/177 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	70/293 (24%)
NPFFR1	NP_071429.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		2/5 (40%)
		7tm_GPCRs	44..340	CDD:333717	76/319 (24%)
		TM helix 1	46..70	CDD:320095	6/23 (26%)
		TM helix 2	79..101	CDD:320095	10/21 (48%)
		TM helix 3	117..139	CDD:320095	5/21 (24%)
		TM helix 4	160..176	CDD:320095	2/15 (13%)
		TM helix 5	214..237	CDD:320095	8/31 (26%)
		TM helix 6	266..291	CDD:320095	7/24 (29%)
		TM helix 7	308..333	CDD:320095	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910