Protein Alignment AdoR and Htr1f

DIOPT Version :9

• Sequence 1: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_068629.2
• Gene: Htr1f / 60448
• RGDID: 71083
• Length: 366
• Species: Rattus norvegicus
• Alignment Length: 382
• Identity: 98/382 - (25%)
• Similarity: 164/382 - (42%)
• Gaps: 85/382 - (22%)

  Fly    29 DAKDSDSPSSEL--NIPYTVFEVL----VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMAD 87
            ::.|.:..|.||  .:|..:...|    :|:::...|.|||......|||....||.|.|||:.|
  Rat     5 NSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVITAIIVTRKLHHPANYLICSLAVTD 69

  Fly    88 LLVGALGIPFAI--------LASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYP 144
            .||..|.:||:|        :...||      |...:|:.::.|:.||..|.|:::|||.||...
  Rat    70 FLVAVLVMPFSIVYIVSESWIMGQGL------CDLWLSVDIICCSCSILHLSAIALDRYRAITDA 128

  Fly   145 MAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLV---FLYFAT 206
            :.|:|....|.|...|:..||....:...|||..|...:.:.:|    ::.::::|   :..|..
  Rat   129 VEYARKRTPRHAGITITTVWVISVFISMPPLFWRHQGNSRDDQC----IIKHDHIVSTIYSTFGA 189

  Fly   207 IITPALLMLAFYTHIYR----------------------VII----KQVRQIVT--------MNP 237
            ...|.:|:|..|..|||                      |::    |.::.:.|        .:|
  Rat   190 FYIPLVLILILYYKIYRAARTLYHKRQASRMIKEELNGQVLLESGEKSIKLVSTSYMLEKSLSDP 254

  Fly   238 ASDLSRRSSAAVVQVTTP----------GRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMIC 292
            ::|..|..|.    |.:|          .|...:||          |:.||...|.:|:..|:||
  Rat   255 STDFDRIHST----VKSPRSELKHEKSWRRQKISGT----------RERKAATTLGLILGAFVIC 305

  Fly   293 WIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            |:|.:....:...|..|.:..:::.|...|.:|||.:||::|....:||:.|.:.|:
  Rat   306 WLPFFVKELVVNICEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLV 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	53/178 (30%)
		7tm_1	58..334	CDD:278431	86/330 (26%)
Htr1f	NP_068629.2	7tm_1	41..347	CDD:278431	86/329 (26%)
		7tm_4	41..>222	CDD:304433	55/190 (29%)
		Agonist binding. /evidence=ECO:0000250	99..108		1/8 (13%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	120..122		1/1 (100%)
		Agonist binding. /evidence=ECO:0000250	306..310		2/3 (67%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	343..347		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910