DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Cnr2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_065418.3	Gene:	Cnr2 / 57302	RGDID:	619713	Length:	410	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	95/402 - (23%)
Similarity:	163/402 - (40%)	Gaps:	81/402 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNY-YIVSLAMADLLVGAL----GIP 96
            |....|...|...|:.::|.:.||.|:.:....::|||:.:| :|.|||.||.|...:    .:.
  Rat    29 SDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVI 93

  Fly    97 FAILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIIS 161
            |.:...:. .||:.  |..:..:.:..|.|:..|:..:||||..:.||..|...|....|:..:.
  Rat    94 FHVFHGVD-SRNIF--LLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALG 155

  Fly   162 MCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVII 226
            :.||...::.:|||.||....:...| ||..:.:...|.:|.|..|:...::    ||:.| |:.
  Rat   156 VMWVLSALISYLPLMGWTCCPSPCSE-LFPLIPNDYLLGWLLFIAILFSGII----YTYGY-VLW 214

  Fly   227 KQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKR-DVKATQNLSIIVLFFM 290
            |..:.:.::....|                        .:|.|.||.| ||:..:.|.:::...:
  Rat   215 KAHQHVASLAEHQD------------------------RQVPGIARMRLDVRLAKTLGLVMAVLL 255

  Fly   291 ICWIPLYTINCIKAFCPDCYVHPKLT----------LFCIILSHLNSAVNPVLYAYHLKDFRAAL 345
            |||.|...:          ..|..:|          .||.:|..:||.:||::||....:.|:|.
  Rat   256 ICWFPALAL----------MGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAA 310

  Fly   346 KNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYV--GEYSPIWLRQQQEALKN 408
            ::.|                   ...:..||.:.|..:...|:..|  .|...:.|:.:|| |..
  Rat   311 QHCL-------------------TGWKKYLQGLGSEGKEEAPKSSVTETEAETLVLKDKQE-LGG 355

  Fly   409 SQLLPKCGVVSP 420
            ..||....:.||
  Rat   356 DCLLRTSSIHSP 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/172 (27%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	71/291 (24%)
Cnr2	NP_065418.3	7tmA_CB2	34..310	CDD:320463	78/318 (25%)
		TM helix 1	36..60	CDD:320463	6/23 (26%)
		TM helix 2	70..91	CDD:320463	8/20 (40%)
		TM helix 3	107..129	CDD:320463	4/21 (19%)
		TM helix 4	152..168	CDD:320463	2/15 (13%)
		TM helix 5	187..210	CDD:320463	6/26 (23%)
		TM helix 6	244..266	CDD:320463	5/31 (16%)
		TM helix 7	278..303	CDD:320463	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910