DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and LOC563567

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_005158584.1	Gene:	LOC563567 / 563567	-ID:	-	Length:	447	Species:	Danio rerio

Alignment Length:	471	Identity:	122/471 - (25%)
Similarity:	210/471 - (44%)	Gaps:	88/471 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 HAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRR-TNYYIVSLAM 85
            |.|...:|....:|..:.|.  :.:|  |:.:.:::||.||.....:.|.||.: ||::::|||:
Zfish    19 HGAQEREDGDGQNSVRALLG--FVLF--LLIVSTLLGNTLVCAAVVKFRHLRSKVTNFFVISLAV 79

  Fly    86 ADLLVGALGIPF-AILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSR 149
            :||.|..|.:|: ||.|..|.......|...::..::..|.||..|..:||||||||..|..|.|
Zfish    80 SDLFVAVLVMPWEAISAVAGTWLFGRFCGIWIAFDIMCSTASILNLCIISVDRYWAIASPFRYER 144

  Fly   150 NVRTRTAIFIISMCWVAGTIVGFLPL-FGWH-AD----------VNHNQECLFVEVMDYNYLVFL 202
            .:..|.|..:|.:.|....::.|:|: ..|| ||          .:::..|  ...::..|.:..
Zfish   145 KMTHRVAFMMIGVAWTLSILISFIPVQLNWHMADDDEEGAGGNGTDYSDNC--KANLNRTYAISS 207

  Fly   203 YFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPA----------SDLSRRSSAAVVQVTTPGR 257
            ...:...|.::|:|.||.|:|:...|:|:|.::..|          :|.|..:|
Zfish   208 SLISFYIPVIIMIATYTRIFRIAQTQIRRISSLERAVEHAQNHHQSNDCSNENS----------- 261

  Fly   258 GGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIIL 322
                      |....|::.|..:.||||:..|:.||:|.:.:||:..|| .|......|:| :..
Zfish   262 ----------LKTTFKKETKVLKTLSIIMGVFVFCWLPFFVLNCMVPFC-QCVSDTTFTIF-VWF 314

  Fly   323 SHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNM-RSTQ 386
            ...||::|||:||:: .|||.|..::|    |.:....:.|:...:.:::......|:.: :..|
Zfish   315 GWANSSLNPVIYAFN-ADFRKAFSSIL----GCNKIFPSTAVETVNFSNELVSYHHDTTLQKEAQ 374

  Fly   387 PRLYVGEYSPIWLRQQQEALKNSQLLPKCGVVSPCFNNINQTVAAVASVTTDLEREMWNIVEASS 451
            |           |..|....:..|.||        |:.        .|||:::.|...|::..:.
Zfish   375 P-----------LAAQMANTREEQSLP--------FDK--------DSVTSNVSRNHKNMLLPNI 412

  Fly   452 GA-EL-GETSYEFPSP 465
            |. |. ||.|.:..:|
Zfish   413 GQFECDGEISLDTITP 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	53/181 (29%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	86/299 (29%)
LOC563567	XP_005158584.1	7tmA_D1-like_dopamine_R	35..336	CDD:320185	94/330 (28%)
		TM helix 1	36..62	CDD:320185	7/29 (24%)
		TM helix 2	70..97	CDD:320185	12/26 (46%)
		TM helix 3	107..137	CDD:320185	12/29 (41%)
		TM helix 4	149..169	CDD:320185	5/19 (26%)
		TM helix 5	200..230	CDD:320185	8/29 (28%)
		TM helix 6	267..297	CDD:320185	12/29 (41%)
		TM helix 7	305..330	CDD:320185	9/26 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910