DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and tshr

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001139235.1	Gene:	tshr / 560609	ZFINID:	ZDB-GENE-110524-4	Length:	757	Species:	Danio rerio

Alignment Length:	412	Identity:	91/412 - (22%)
Similarity:	167/412 - (40%)	Gaps:	98/412 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 AKDSDSPSSELNIPYTVFEV---LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVG 91
            |.|..:|..:: :.::...|   .|::::::||:||::|..........:.:.:..||:|||
Zfish   400 APDEFNPCEDI-MGFSFLRVSVWFVSLLAVLGNLLVLLVLLTSHYKLSVSRFLMCHLAVADL--- 460

  Fly    92 ALGIPFAILASMGLPRNL----HA--------CLFTVSLLVVLCTISIFCLVAVSVDRYWAILYP 144
            .:||...::||:.|....    ||        |.......|....:|::.|..::::|::||.|.
Zfish   461 CMGIYLLLIASVDLHTQSEYYNHAIDWQTGPGCSLAGFFSVFASELSVYTLTTITLERWYAITYA 525

  Fly   145 MAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLV-FLYFATII 208
            |...|.:|...|..|:.:.|:...::|.:||.|    |:..|:......||...|| .:|...::
Zfish   526 MRLDRKLRLSHASVIMLIGWIFCLLLGLMPLVG----VSSYQKVSICLPMDTQTLVDQIYIICVL 586

  Fly   209 TPALLMLAF------YTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRV 267
              .|.:|||      |..||..:         .||    |.:||
Zfish   587 --VLNILAFIVICVCYIKIYCAV---------HNP----SHQSS--------------------- 615

  Fly   268 LGAARKRDVKATQNLSIIVLFFMICWIP--LYTINCIKAFCPDCYVHPKLT-----LFCIILSHL 325
                 .:|....:.:::::....:|..|  ||.:..:       ..||.:|     :..::...|
Zfish   616 -----NKDTNIAKRMAVLIFTDFLCMAPISLYAMTAV-------LDHPLITVSNSKILLVLFYPL 668

  Fly   326 NSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVAS--------QHRLQSMDSNM 382
            ||..||.|||...|.|:..: .:||..:|: ..:||:.....:|:|        :|..:...:|.
Zfish   669 NSCANPFLYAIFTKAFQGDV-FILLSKVGL-CQRQAQLFRGQTVSSKASSRGITRHEREQTGANE 731

  Fly   383 RSTQPRLYVGEYSPIWLRQQQE 404
            .......:.|:.:   ..||||
Zfish   732 TPISLLDFPGKMA---AAQQQE 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	47/186 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/301 (22%)
tshr	NP_001139235.1	leucine-rich repeat	52..75	CDD:275380
		leucine-rich repeat	76..100	CDD:275380
		LRR_5	101..224	CDD:290045
		leucine-rich repeat	101..125	CDD:275380
		leucine-rich repeat	145..175	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		leucine-rich repeat	200..224	CDD:275380
		7tm_1	446..677	CDD:278431	62/285 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910