DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and nmur1a

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_021325138.1	Gene:	nmur1a / 557276	ZFINID:	ZDB-GENE-081104-220	Length:	428	Species:	Danio rerio

Alignment Length:	388	Identity:	100/388 - (25%)
Similarity:	171/388 - (44%)	Gaps:	85/388 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIP------ 96
            |.:.:|..:..:|:.:|..:||:|..||..:.:.:|..||:|:.|||::||||..||:|
Zfish    56 SPVFLPVCLTYLLIFLVGAVGNILTCIVIAKNKVMRTPTNFYLFSLAISDLLVLLLGMPLELYEM 120

  Fly    97 ---FAILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRT--- 155
               :..|...|      .|.|...|...:|..||..:.|:||:||.|:::|:. ::.|.|||
Zfish   121 WSNYPFLLGKG------GCYFKTLLFETVCFASILNVTALSVERYIAVIHPLR-AKYVVTRTHAK 178

  Fly   156 ----AIFIIS-MCWVAGTIVGFL----PLFGWHADVN-HNQECLFVEVMDYNYLVFLYFATIITP 210
                :::.|| :|.:..||:..:    |..|..|.|. .:..|:.|:.. :.|.:.:...|::..
Zfish   179 RLILSVWSISVLCAIPNTILHGIFTLPPPKGKAAGVMLDSATCMLVKPR-WMYNLIIQITTLLFF 242

  Fly   211 ALLMLAFYTHIYRVIIKQVR-----QIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGA 270
            .|.||.. :.:|.:|..|::     |::....:|.|...|:....|..|
Zfish   243 LLPMLTI-SVLYLLIGMQLKREKMLQVLEAKASSGLDSSSNVRSQQQKT---------------- 290

  Fly   271 ARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDC------------YVHPKLTLFCIILS 323
             |::.|  |:.|.::|:.|.|||.|.:|...:.:|....            |||    :...:..
Zfish   291 -RRQQV--TKMLFVLVVMFGICWAPFHTDRLMWSFMDQKDSEHIEIFEVYEYVH----VISGVFF 348

  Fly   324 HLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDS-NMRST 385
            :|:||:|||||......||...|.::..             |::....:.|..||.. .:|||
Zfish   349 YLSSAINPVLYNLMSTRFREMFKEVMCH-------------HKWRPVPRKRSLSMTRVTVRST 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	55/189 (29%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	84/314 (27%)
nmur1a	XP_021325138.1	7tmA_NMU-R1	60..370	CDD:320480	91/341 (27%)
		TM helix 1	60..87	CDD:320480	8/26 (31%)
		TM helix 2	94..120	CDD:320480	13/25 (52%)
		TM helix 3	133..163	CDD:320480	12/29 (41%)
		TM helix 4	175..197	CDD:320480	4/21 (19%)
		TM helix 5	230..259	CDD:320480	7/29 (24%)
		TM helix 6	290..320	CDD:320480	12/48 (25%)
		TM helix 7	338..363	CDD:320480	11/28 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910