Protein Alignment AdoR and adrb1

DIOPT Version :10

• Sequence 1: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001122161.1
• Gene: adrb1 / 557194
• ZFINID: ZDB-GENE-081022-145
• Length: 390
• Species: Danio rerio
• Alignment Length: 344
• Identity: 104/344 - (30%)
• Similarity: 157/344 - (45%)
• Gaps: 50/344 - (14%)

  Fly    30 AKDSDSPSSELNIP------YTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADL 88
            :.||...:.:||:.      ..:...|:..|.::||:|||:...|.::|:..||.:|||||.|||
Zfish    11 SNDSKRATVDLNVSEQWLVGMGILMGLIVFVIVVGNILVIVAIARNQRLQTLTNVFIVSLACADL 75

  Fly    89 LVGALGIPF-AILASMGL-PRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNV 151
            ::|.|.:|| |.|...|. ......|.|.:||.|:..|.||..|..:::|||.||:.|..|...:
Zfish    76 IMGLLVVPFGAALEVRGAWMYGSFFCEFWISLDVLCVTASIETLCVIAIDRYIAIISPFRYQSLL 140

  Fly   152 RTRTAIFIISMCWVAGTIVGFLP-LFGWHADVN-----HNQECLFVEVMDYNYLVFLYFATIITP 210
            ....|..::...|....:|.|.| |..|..|..     .|.||... |.:..|.:.....:...|
Zfish   141 TKARAKVVVCAVWAISALVSFPPILMHWSQDSEETSCYENPECCDF-VTNRAYAISSSIISFYIP 204

  Fly   211 ALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGR--GGHTGTMLRVLGAARK 273
            .::|:..|..:||...:|:.:|   |...                ||  ..| ||..:   ..||
Zfish   205 LIVMIFVYARVYREAKQQLNKI---NKCE----------------GRFYNNH-GTNCK---PTRK 246

  Fly   274 R--------DVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVN 330
            |        :.||.:.|.||:..|.:||:|.:.:|.::.||.. .|..:|.:|...|.::|||.|
Zfish   247 RTTKILALKEQKALKTLGIIMGTFTLCWLPFFIVNVVRVFCAQ-VVDKELFVFLNWLGYVNSAFN 310

  Fly   331 PVLYAYHLKDFRAALKNLL 349
            |::|. ...|||.|.|.||
Zfish   311 PIIYC-RSPDFRKAFKRLL 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tmA_Adenosine_R	42..345	CDD:341316	96/326 (29%)
		TM helix 1	43..69	CDD:341316	7/31 (23%)
		TM helix 2	76..103	CDD:341316	16/27 (59%)
		TM helix 3	112..142	CDD:341316	13/29 (45%)
		TM helix 4	156..174	CDD:341316	4/17 (24%)
		TM helix 5	196..225	CDD:341316	6/28 (21%)
		TM helix 6	273..303	CDD:341316	12/37 (32%)
		TM helix 7	313..338	CDD:341316	9/24 (38%)
adrb1	NP_001122161.1	7tm_GPCRs	30..324	CDD:475119	96/319 (30%)
		TM helix 1	31..55	CDD:320624	7/23 (30%)
		TM helix 2	64..86	CDD:320624	13/21 (62%)
		TM helix 3	102..124	CDD:320624	8/21 (38%)
		TM helix 4	147..163	CDD:320624	3/15 (20%)
		TM helix 5	190..213	CDD:320624	3/22 (14%)
		TM helix 6	260..282	CDD:320624	7/21 (33%)
		TM helix 7	293..318	CDD:320624	9/25 (36%)