DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and GPR173

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_061842.1	Gene:	GPR173 / 54328	HGNCID:	18186	Length:	373	Species:	Homo sapiens

Alignment Length:	371	Identity:	97/371 - (26%)
Similarity:	153/371 - (41%)	Gaps:	67/371 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AATTSKDAKDSD--SPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAM 85
            |.||.:..:.|.  ||.|.......|...|:..||:.||.::.::..:||.|.:...|:::.|.:
Human     2 ANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCL 66

  Fly    86 ADLLVGALGIPFAILASMGLPRNLHACLFTVSLL---------VVLCTISIFCLVAVSVDRYWAI 141
            ||.:..|:..|| :|||:     .|...:|.|.|         |:.|..:.|.|..:||.||.||
Human    67 ADGIRSAVCFPF-VLASV-----RHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAI 125

  Fly   142 LYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLF--GWHADVNHNQECLFVEVMDYNY------ 198
            .:...|::.:...|...:|.|.|.....:.|.|:|  |.:..:....:|:|    ::.|
Human   126 AHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF----EHRYFKANDT 186

  Fly   199 ------LVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRR---------SSAA 248
                  |..|..||......|:|..|.|       :..:.|.|.||  :|:.         ..||
Human   187 LGFMLMLAVLMAATHAVYGKLLLFEYRH-------RKMKPVQMVPA--ISQNWTFHGPGATGQAA 242

  Fly   249 VVQVTTPGRGGHTGTML--RVLGAARKR------DVKATQNLS----IIVLFFMICWIPLYTINC 301
            ...:...|||....|:|  |..|.|..|      :||..:.|.    .|.|.|::.|.| |.:.|
Human   243 ANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSP-YIVAC 306

  Fly   302 I-KAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALK 346
            . :.|...|.|..:.....:.:|...:||||::.....||.:..|:
Human   307 YWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLR 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	50/190 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	83/320 (26%)
GPR173	NP_061842.1	7tmA_SREB3_GPR173	23..351	CDD:320345	89/347 (26%)
		TM helix 1	25..49	CDD:320345	6/23 (26%)
		TM helix 2	58..80	CDD:320345	7/22 (32%)
		TM helix 3	97..119	CDD:320345	4/21 (19%)
		TM helix 4	142..158	CDD:320345	4/15 (27%)
		TM helix 5	184..207	CDD:320345	4/22 (18%)
		TM helix 6	285..307	CDD:320345	6/22 (27%)
		TM helix 7	319..344	CDD:320345	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910