DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Lpar2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001102579.2	Gene:	Lpar2 / 498609	RGDID:	1561336	Length:	348	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	74/328 - (22%)
Similarity:	144/328 - (43%)	Gaps:	47/328 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DSPSSELNIPYTVFEVL-------VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVG 91
            ::...||::.:...:|:       |:::.::.|:|||......|:..:...|.:.:||.|||..
  Rat    15 NNSGKELSLHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFA- 78

  Fly    92 ALGIPFAILASMGLPR----NLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVR 152
              |:.:..|.....||    ::........||....|.|:..|:|::|:|:.:::....:||..|
  Rat    79 --GMAYLFLMFHTGPRTARLSIKGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPR 141

  Fly   153 TRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAF 217
            .|....|:.: |||...:|.||...||...:.:.....|.:...:||.....::::. .|||:|.
  Rat   142 GRVVTLIVGV-WVAALGLGLLPAHFWHCLCDLDSCSRMVPLFSRSYLAVWALSSLLV-FLLMVAV 204

  Fly   218 YTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNL 282
            ||.|:..:.::|.::..........|.::.::|:           |::.:|||
  Rat   205 YTRIFFFVRRRVERMAEHVSCHPRYRETTLSLVK-----------TVVIILGA------------ 246

  Fly   283 SIIVLFFMICWIPLYTINCIKAF-CPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALK 346
                  |::||.|...:..:... |..|.| ..:..:.::|:..||.||.|:|:....:.|...:
  Rat   247 ------FVVCWTPGQVVLLLDGLDCKSCNV-LAVEKYFLLLAEANSLVNAVVYSCRDAEMRRTFR 304

  Fly   347 NLL 349
            .||
  Rat   305 RLL 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	44/171 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	66/280 (24%)
Lpar2	NP_001102579.2	7tm_GPCRs	30..303	CDD:421689	70/307 (23%)
		TM helix 1	31..57	CDD:410628	5/25 (20%)
		TM helix 2	64..89	CDD:410628	8/27 (30%)
		TM helix 3	101..131	CDD:410628	8/29 (28%)
		TM helix 4	144..162	CDD:410628	5/18 (28%)
		TM helix 5	182..211	CDD:410628	9/29 (31%)
		TM helix 6	231..261	CDD:410628	9/58 (16%)
		TM helix 7	271..296	CDD:410628	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910