DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Lgr6

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_573455.1	Gene:	Lgr6 / 498233	RGDID:	1560339	Length:	965	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	100/530 - (18%)
Similarity:	150/530 - (28%)	Gaps:	263/530 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 VAIVSIIGNVLVII-VFRRERKLRRRTNYYIVSLAMADLLVGAL-------GIPFAILASM---- 103
            :.::|::.|.||:: ||.....          .|:...|:|||:       ||...:|||:
  Rat   571 IVLLSVLCNGLVLLTVFAGGPS----------PLSPVKLVVGAIAGANALTGISCGLLASVDALT 625

  Fly   104 -------------GL---------PRNLHACLFTVSLLVVLCTISIFCLVA-------------- 132
                         ||         .....|.:..::|..|.|::|:.|:.|
  Rat   626 FGQFAEYGARWETGLGCQATGFLAVLGSEASVLLLTLAAVQCSVSVTCVRAYGKAPSPGSVRAGA 690

  Fly   133 ---------------VSVDRYWA----ILYPMAYSRNVRTRTAIFII---SMCW--VAGTIVGF- 172
                           .||..|.|    :.|.....|......|:.::   |:|:  |||..:..
  Rat   691 LGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLY 755

  Fly   173 --LPLFGWH-----ADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVR 230
              ||...:.     |.|.|....:|.:.:.|..:.||.||:       ||..:.
  Rat   756 CDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFAS-------MLGLFP----------- 802

  Fly   231 QIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIP 295
                                  .||                     :|.:::.::||       |
  Rat   803 ----------------------VTP---------------------EAVKSVLLVVL-------P 817

  Fly   296 LYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQ 360
            |          |.|                   :||:||......||..|:.|.
  Rat   818 L----------PAC-------------------LNPLLYLLFNPHFREDLRRLW----------- 842

  Fly   361 AEAIHRFSVASQHRLQSMDSNMRSTQPRLY--VGEYSPIWLRQQQEALKNSQLLPKCGVVSPCFN 423
                               .:.||..|..|  .||                  |.|    |.|
  Rat   843 -------------------PSPRSPGPLAYTAAGE------------------LEK----SSC-- 864

  Fly   424 NINQTVAAVASVTTDLEREMWNIVEAS-SGAELGETSYEFPSPA------PGSQRSS-----ERN 476
              :.|.|.||....||      |:||| :|...|..:|.|||..      ||:.|..     |.:
  Rat   865 --DSTQALVAFSDVDL------ILEASEAGQPPGLETYGFPSVTLISRHQPGATRLEGNHFVEPD 921

  Fly   477 SSSTVPPAPP 486
            .:....|.||
  Rat   922 GTKLGNPQPP 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	50/247 (20%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	60/355 (17%)
Lgr6	XP_573455.1	LRRNT	34..68	CDD:214470
		LRR_RI	<70..248	CDD:238064
		leucine-rich repeat	70..91	CDD:275380
		LRR_8	92..150	CDD:290566
		leucine-rich repeat	92..115	CDD:275380
		leucine-rich repeat	116..139	CDD:275380
		LRR_8	138..198	CDD:290566
		leucine-rich repeat	140..163	CDD:275380
		leucine-rich repeat	164..187	CDD:275380
		LRR_8	186..246	CDD:290566
		leucine-rich repeat	188..211	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..258	CDD:275380
		LRR_RI	253..>442	CDD:238064
		LRR_8	258..314	CDD:290566
		leucine-rich repeat	259..282	CDD:275380
		leucine-rich repeat	283..304	CDD:275380
		LRR_8	305..364	CDD:290566
		leucine-rich repeat	330..344	CDD:275378
		leucine-rich repeat	354..375	CDD:275380
		LRR_8	375..434	CDD:290566
		leucine-rich repeat	376..399	CDD:275380
		leucine-rich repeat	400..421	CDD:275380
		leucine-rich repeat	424..444	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910