DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Lgr3

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster

Alignment Length:	405	Identity:	78/405 - (19%)
Similarity:	144/405 - (35%)	Gaps:	127/405 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLPLHAATT---------------SKDAKDSDSPSSELNIPYTVFE------------------- 48
            |:|:|.:::               ..|..|.::.:|..|:.|.:::
  Fly   355 LMPIHISSSLMEPLNISFLNLTGIRYDHIDFEAINSMRNLTYIIYDRFFYCSMTPRVRMCKPSTD 419

  Fly    49 ------------VL------VAIVSIIGNVLVI---IVFRRERKLRRRTNYYIVSLAMADLLVGA 92
                        ||      :|.::|.|||||:   .::|.|..   .....|.:||:||:|:|
  Fly   420 GVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENV---AVTMVIRNLALADMLMG- 480

  Fly    93 LGIPFAILASMGLP----RNLH-----------ACLFTVSLLVVLCTISIFCLVAVSVDRYWAIL 142
                 ..|.::|:.    ||.:           .|....:|.|....:|:..|..:|::|:..|.
  Fly   481 -----FYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIA 540

  Fly   143 YPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADV-----NHNQECLFVEVMDYNYLVFL 202
            .|....|::..|.....:...|:.|..:...|:..|....     :::..|..:.:.:...:.:|
  Fly   541 DPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGTCFPLHIHEAFPMGWL 605

  Fly   203 YFATIITPA-LLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLR 266
            |.|.:.... ||:|.....:|..::..:.:..:..|.                        |:|
  Fly   606 YSAFVFLGVNLLLLVMIAMLYTALLISIWRTRSATPL------------------------TLL- 645

  Fly   267 VLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAF----CPDCYVHPKLTLFCIILSHLNS 327
                    |.:.......|||...:||:|:..:.....|    ..|.|..  |.:|.:   .|||
  Fly   646 --------DCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIYAW--LVVFVL---PLNS 697

  Fly   328 AVNPVLYAYHLKDFR 342
            ||||:||.:....:|
  Fly   698 AVNPLLYTFTTPKYR 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	42/191 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	63/303 (21%)
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566
		leucine-rich repeat	181..204	CDD:275380
		LRR_RI	<196..354	CDD:238064
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		leucine-rich repeat	253..275	CDD:275380
		LRR_8	274..334	CDD:290566
		leucine-rich repeat	276..299	CDD:275380
		leucine-rich repeat	300..323	CDD:275380
		leucine-rich repeat	324..347	CDD:275380
		7tm_1	447..704	CDD:278431	63/303 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910