DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and MC2R

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_000520.1	Gene:	MC2R / 4158	HGNCID:	6930	Length:	297	Species:	Homo sapiens

Alignment Length:	346	Identity:	78/346 - (22%)
Similarity:	140/346 - (40%)	Gaps:	100/346 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGI- 95
            :||.|  .:.:|..:| ..::||.::.|::|::...:.:.|:....::|.|||::|:|.....|
Human    18 NSDCP--RVVLPEEIF-FTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKIL 79

  Fly    96 --PFAILASMGL--PR--------NLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYS 148
              ...||.:||.  ||        ::...||.:|||.     |||.|..::.|||..|.:.:.|.
Human    80 ENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLG-----SIFSLSVIAADRYITIFHALRYH 139

  Fly   149 RNVRTRTAIFIISMCWVAGTIVGF-LPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIIT--- 209
            ..|..|..:.::::.|...|..|. :.:|..|.                        .|:||
Human   140 SIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHV------------------------PTVITFTS 180

  Fly   210 --PALL--MLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGA 270
              |.:|  :|..|.|::.:.....|:|.|:..|
Human   181 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRA-------------------------------- 213

  Fly   271 ARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPD-----CYVHPKLTLFCI--ILSHLNSA 328
                ::|....|:|::..|:.||.|......:..|||.     ||    ::||.:  :|...|:.
Human   214 ----NMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACY----MSLFQVNGMLIMCNAV 270

  Fly   329 VNPVLYAYHLKDFRAALKNLL 349
            ::|.:||:...:.|.|.|.::
Human   271 IDPFIYAFRSPELRDAFKKMI 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/188 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	66/303 (22%)
MC2R	NP_000520.1	7tmA_MC2R_ACTH_R	25..287	CDD:320472	73/331 (22%)
		TM helix 1	26..52	CDD:320472	6/26 (23%)
		TM helix 2	59..85	CDD:320472	7/25 (28%)
		TM helix 3	103..133	CDD:320472	12/34 (35%)
		TM helix 4	145..165	CDD:320472	4/19 (21%)
		TM helix 5	170..199	CDD:320472	9/52 (17%)
		TM helix 6	212..242	CDD:320472	8/65 (12%)
		TM helix 7	255..280	CDD:320472	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910