DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and 5-HT2B

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001262373.1	Gene:	5-HT2B / 41017	FlyBaseID:	FBgn0261929	Length:	947	Species:	Drosophila melanogaster

Alignment Length:	831	Identity:	190/831 - (22%)
Similarity:	305/831 - (36%)	Gaps:	189/831 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LHAATTSKDAKDSDSPSSELNIPYTV--FEVLVAIVSII----GNVLVIIVFRRERKLRRRTNYY 79
            ||.|..:.....:.|.:.| ::|:..  :..|:|:|.::    ||:||.:....||:|:..|||:
  Fly    48 LHVARWNATGNATISATFE-DVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYF 111

  Fly    80 IVSLAMADLLVGALGIPFAILASMG--LPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAIL 142
            ::|||:.||:|..|.:|..||..:.  .|.....||..:.|.|:.||.||..|..:|||||.::.
  Fly   112 LMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLR 176

  Fly   143 YPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGW----HADVNHNQECLFVEVMDYNYLVFLY 203
            |||.:.||...|.....|...|:. :|...|||...    ||.|..|..|   ::.|..|.:...
  Fly   177 YPMRFGRNKTRRRVTLKIVFVWLL-SIAMSLPLSLMYSKNHASVLVNGTC---QIPDPVYKLVGS 237

  Fly   204 FATIITPALLMLAFYTHIYRVIIKQ------VRQIVTMNP---------ASDLSRRSSAAVVQVT 253
            ......|..:||..|....|::.:|      .:|.....|         |..|.||.:..  ::.
  Fly   238 IVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWR--RLL 300

  Fly   254 TPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLF 318
            .||.|..:..:......:...|:....|..:        |:            ||
  Fly   301 KPGPGNASSVLHAHSANSTDTDLSTLDNHEL--------WL------------PD---------- 335

  Fly   319 CIILSHLNSAVNPVLYAYHLKDFRAALKNLL--LKMMGVDIDQQAEAIHRFSVASQHRLQSMDSN 381
                |.:.......:.|.|  .|.|.:..|.  |:.:.......:.....||:::..:||...|
  Fly   336 ----SSIKEPTPTTMTALH--QFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSS- 393

  Fly   382 MRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPKCGV----VSPCFNNINQTVAAVASVTTDLERE 442
                 |:.|...:       ||....|.|..| .||    .||...: ..||..:::.|..:|||
  Fly   394 -----PQRYAATH-------QQSHHHNHQQHP-AGVYHQQASPKGRH-GTTVLGLSTTTLGIERE 444

  Fly   443 MWNIVEASS--GAE-----LGETSYEF---------PSPAPGSQRSSERNSSSTVPPAPPAPAK- 490
            ......|||  |.|     |.:.|...         .|..||.::.:....:......|.:..:
  Fly   445 STRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRR 509

  Fly   491 ----PSVP-SASYDNH---NYSFSQDEDEDDDDLEFEDVFVPASSVPNPVQPGIDPVELRRSLAL 547
                .|:| :|.|..|   ..|...|:||:::..:.:|....:....:..:  :||.:..:...:
  Fly   510 HKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTE--LDPPQKAKQCHI 572

  Fly   548 VMRE------KLRSDDT----DSRPMGN---NQDLPIDEQSRERPLSTQTSPTNGP--------- 590
            ..:.      :|.|..|    ..||:.|   :.::.| ..|..|..:|.|:.::.|
  Fly   573 AGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKI-ISSAFRVTTTTTAVSSSPSEMELLMCS 636

  Fly   591 ------LPALLRAKLLAGNSNSAHCLPGSTASP-APQEQSGIFVIDSE-----ASPGSNGHKPKY 643
                  |.:.:.|.:..|.:.:|....|||.|| :...|.....:.|:     |:||:  ..|..
  Fly   637 SGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGT--PCPGR 699

  Fly   644 RKGTAFTRSSLKKSRSCNCSSIAKGRGVHDEPSSNLCRDQES------SVLPQHPQPANHPTENF 702
            ||                 .||:|...|....||...|...|      |:|....:.|.  |.|.
  Fly   700 RK-----------------LSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTAT--TSNS 745

  Fly   703 FSPLRSVGSFMQHSNLFHFLQPHAARPTSSTASSTASTPTPSPPPMGQAQE 753
            .:|||...:...|.|:.:.........|.:|.||         |.|.|.|:
  Fly   746 STPLRRSATLRSHQNMNYQGAGECGGKTRTTTSS---------PCMLQRQQ 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	60/177 (34%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	75/296 (25%)
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	59/175 (34%)
5-HT2B	NP_001262373.1	7tm_4	90..>238	CDD:304433	54/151 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910