DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and lhcgr

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_991188.1	Gene:	lhcgr / 402920	ZFINID:	ZDB-GENE-040806-3	Length:	708	Species:	Danio rerio

Alignment Length:	419	Identity:	84/419 - (20%)
Similarity:	155/419 - (36%)	Gaps:	83/419 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FSITDFSFEGPLLPL----HAATTSKDAKDSDSPSSELNIPYTVFEV---LVAIVSIIGNVLVII 64
            |...||.:  |.|.|    .|...|.:| |:.:|..:: ..::...|   .:.|::|.||::|::
Zfish   332 FGSIDFHY--PDLDLCQQRQALQCSPEA-DAFNPCEDI-AGFSFLRVAIWFINILAIAGNLVVLL 392

  Fly    65 VFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLH------------ACLFTVS 117
            |....|.......:.:..||.|||   .:||...::|::.|....|            .|.....
Zfish   393 VLFTSRCKLTVPRFLMCHLAFADL---CIGIYLLMIATVDLRTRGHYSHHAIEWQTGAGCDIAGF 454

  Fly   118 LLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADV 182
            |.|....:||:.|..::|:|:..|.:.:...|.:....|..|:::.|:....:..|||.| .:..
Zfish   455 LSVFGGELSIYTLSTITVERWHTITHALRLERRLGLSQASLIMTIGWLLCLAMALLPLIG-VSSY 518

  Fly   183 NHNQECLFVEV---MDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRR 244
            :....||.:::   :...|::.|.... :...|::...|..||..:         .||
Zfish   519 SKVSMCLPMDIETPLSQAYVILLLLFN-VGAFLVICGCYVCIYSAV---------RNP------- 566

  Fly   245 SSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDC 309
                    ..|||..               |.|..:.:::::....:|..|:.......||....
Zfish   567 --------EFPGRAA---------------DAKIAKRMAVLIFTDFLCMAPISFFAISAAFKVPL 608

  Fly   310 YVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHR 374
            .......:..::...:||..||.|||...:.||   |:..:.:..:...|....::|........
Zfish   609 ITVTNSKILLVLFYPINSCANPFLYAIFTRAFR---KDACILLSSMGCCQSKANLYRMKTYCSEN 670

  Fly   375 L----QSMDSNMRSTQPRLYVGEYSPIWL 399
            :    .|..||..|..||      :.:|:
Zfish   671 INRSKSSSGSNANSKGPR------AVMWM 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/182 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	55/290 (19%)
lhcgr	NP_991188.1	leucine-rich repeat	47..70	CDD:275380
		LRR_5	58..216	CDD:290045
		leucine-rich repeat	71..95	CDD:275380
		leucine-rich repeat	96..120	CDD:275380
		leucine-rich repeat	121..142	CDD:275380
		leucine-rich repeat	143..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..219	CDD:275380
		leucine-rich repeat	220..257	CDD:275380
		GnHR_trans	283..356	CDD:289164	8/25 (32%)
		7tm_1	386..633	CDD:278431	55/290 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910