DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and p2ry2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_989039.1	Gene:	p2ry2 / 394636	XenbaseID:	XB-GENE-1005097	Length:	349	Species:	Xenopus tropicalis

Alignment Length:	358	Identity:	82/358 - (22%)
Similarity:	149/358 - (41%)	Gaps:	83/358 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLL 89
            :|.|...|.|.....|.:.|.:    |..|.:|.|:|.:.:|....|....:..|:.:||::|::
Frog    10 STYKCKFDEDFKYVLLPVSYGI----VFCVGLILNILALYIFLFRIKPWNASTTYMFNLAISDMM 70

  Fly    90 VGALGIPFAI-LASMG--LPRNLHAC-----LFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMA 146
            . .:.:|..: ..|.|  .|..:..|     ||..::   .|:||.  |:.:|:.|:..|.|||.
Frog    71 Y-VISLPLLVYYYSQGDNWPFGVALCKIVKFLFYTNM---YCSISF--LLCISIHRFLGICYPMK 129

  Fly   147 YSRNVRTRTAIFIISMCWV-----AGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFAT 206
            ....::.|.|..|..:.||     ...|:.|:.... :.|.....:...|::.| |::|   ::|
Frog   130 SLGWLKVRNARIISVVVWVIVSACQSPILYFVTTSS-NGDSTTCHDTSSVDLFD-NFVV---YST 189

  Fly   207 IITPALLMLAFYTHI--YRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLG 269
            :....|..:.|.|.|  |.::.:.:     |.|        |||..|.:
Frog   190 VDLALLFCVPFITIIICYCLMARTL-----MKP--------SAATAQTS---------------- 225

  Fly   270 AARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHL--------- 325
            |::|:.:|.   :.|::..|:||::|.:....:      .|...|:.|.|.||:.:
Frog   226 ASKKKSIKM---IIIVLAVFIICFLPFHINRTL------YYYFRKMELDCDILNAINLAYKVTRP 281

  Fly   326 ----NSAVNPVLYAYHLKDFRAAL--KNLLLKM 352
                ||.::|:||....:..|.::  :|.|.||
Frog   282 LASANSCLDPILYFLAGQTVRRSIIPRNGLSKM 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	42/180 (23%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	66/303 (22%)
p2ry2	NP_989039.1	7tmA_P2Y2	23..305	CDD:320495	74/334 (22%)
		TM helix 1	23..50	CDD:320495	8/30 (27%)
		TM helix 2	57..82	CDD:320495	5/25 (20%)
		TM helix 3	95..125	CDD:320495	9/34 (26%)
		TM helix 4	137..159	CDD:320495	6/21 (29%)
		TM helix 5	184..213	CDD:320495	7/31 (23%)
		TM helix 6	226..256	CDD:320495	8/38 (21%)
		TM helix 7	273..298	CDD:320495	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910