DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and FMRFaR

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001261347.1	Gene:	FMRFaR / 38357	FlyBaseID:	FBgn0035385	Length:	549	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	113/540 - (20%)
Similarity:	197/540 - (36%)	Gaps:	167/540 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KDSDSPSSELN-IPYTVFEVLVAIV---SIIGNVLVIIVFRRERKLRRRTNYYIVSLAMAD--LL 89
            :|..:|..|.| |.:.|..||:.||   .|:||::.:|:..|. ::|...||.:..||..|  |:
  Fly    99 EDVYNPLLENNRIEFWVCGVLINIVGVLGILGNIISMIILSRP-QMRSSINYLLTGLARCDTVLI 162

  Fly    90 VGAL---GIPFAILASMG--------LPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILY 143
            :.::   ||| :|....|        :...:...:|.:.::..  |.||:....|:::||.|:.:
  Fly   163 ITSILLFGIP-SIYPYTGHFFGYYNYVYPFISPAVFPIGMIAQ--TASIYMTFTVTLERYVAVCH 224

  Fly   144 PM------AYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQ-------ECL------ 189
            |:      .|.|    ....||:.:|:   ::...:|.|.....|.:.:       .|:
  Fly   225 PLKARALCTYGR----AKIYFIVCVCF---SLAYNMPRFWEVLTVTYPEPGKDVILHCVRPSRLR 282

  Fly   190 ----FVEV-MDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAV 249
                ::.: :.:.||:..|....:|.|:|....|..:.|...::.|          |||
  Fly   283 RSETYINIYIHWCYLIVNYIIPFLTLAILNCLIYRQVKRANRERQR----------LSR------ 331

  Fly   250 VQVTTPGRGGHTGTMLRVLGAARKRDV-KATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHP 313
                                 :.||:: .||..|.::::|||:.::|| .:|..:||...  :..
  Fly   332 ---------------------SEKREIGLATMLLCVVIVFFMLNFLPL-VLNISEAFYST--IDH 372

  Fly   314 KLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLK-MMGVDIDQQAEAIHRFSVAS------ 371
            |:|....:|..:||:||.::|....:.|:.....:..| .:..|   |.:.||..|..|
  Fly   373 KITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLSRD---QPDLIHYESSISNNGDGT 434

  Fly   372 -QHRLQ---SMDSNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPKC--GVVSPCFNNINQTVA 430
             .||..   |.....|||.....|....|..              ..|  |..:...||:..|..
  Fly   435 LNHRSSGRFSRHGTQRSTTTTYLVATGGPGG--------------GGCGGGGGNNSLNNVRLTQV 485

  Fly   431 AVASVTTDLEREMWNIVEASSGAELGETSYEFPSPAP-------GSQRSSERNSSSTVPPAPPAP 488
            :.:.....::|.                  ..|||.|       ..|||:...:|:|
  Fly   486 SGSPGLVKIKRN------------------RAPSPGPVVYFPAREMQRSASTTNSTT-------- 524

  Fly   489 AKPSVPSASYDNHNYSFSQD 508
                       |:|.|...|
  Fly   525 -----------NNNTSIGYD 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	44/207 (21%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	66/313 (21%)
FMRFaR	NP_001261347.1	7tm_4	122..394	CDD:304433	69/322 (21%)
FMRFaR	NP_001261347.1	7tm_1	130..393	CDD:278431	66/313 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910