DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and 5-HT1A

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	710	Identity:	164/710 - (23%)
Similarity:	242/710 - (34%)	Gaps:	202/710 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLL 89
            ||||.|:|..:....:.:. :|...|:.:|:|||||.||.....||.|:...||.:.|||:|||.
  Fly   211 TTSKVAEDDFTQLLRMAVT-SVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLF 274

  Fly    90 VGALGIPFAIL--ASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNV- 151
            |..|.:|...:  .|.|.......|....|..|:.||.||..|||::||||||:       .|:
  Fly   275 VACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAV-------TNID 332

  Fly   152 ----RTRTAIFIISMC-WVAGTIVGFLPLFGWHADVNH-----NQECLFVEVMDYNYLVFLYFAT 206
                ||...:|::..| |.|..||...|.||| .|.::     .|:|:..:  |.:|.||....|
  Fly   333 YIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGW-KDPDYLQRIEQQKCMVSQ--DVSYQVFATCCT 394

  Fly   207 IITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAA 271
            ...|.|::||.|..||:...|::.:   ..|      |...|.|....|..|..|.|.|..|
  Fly   395 FYVPLLVILALYWKIYQTARKRIHR---RRP------RPVDAAVNNNQPDGGAATDTKLHRL--- 447

  Fly   272 RKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAY 336
                                                    ..:|..|....|...|||
  Fly   448 ----------------------------------------RLRLGRFSTAKSKTGSAV------- 465

  Fly   337 HLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHR-LQSMDSNMRSTQPRLYVGEYSPIWLR 400
                             ||.           ..||..| |..:|.|..:|...:...|:|.
  Fly   466 -----------------GVS-----------GPASGGRALGLVDGNSTNTVNTVEDTEFSS---- 498

  Fly   401 QQQEALKNSQLLPKCGVVSPCFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPSP 465
                  .|.....:.||.:|                            ::||.::...|:   ..
  Fly   499 ------SNVDSKSRAGVEAP----------------------------STSGNQIATVSH---LV 526

  Fly   466 APGSQRSSERNSSSTVPPAPPAPAKPSVPSASYDNHNYSFSQDEDEDDDDLEFEDVFVPASSVPN 530
            |...|:......||       |......||...::........|.||.::||.:|
  Fly   527 ALAKQQGKSTAKSS-------AAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQD---------- 574

  Fly   531 PVQPGIDPVELRRSLALVMREKLRSDDTDSRPMGNNQDL---PIDEQSRERPLSTQTSPTNGPLP 592
             .|.|..|.....::...     .:::::.:...|..::   |..:|..|:....|.|..:|...
  Fly   575 -EQVGPQPTTATSAMTAA-----GTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGG 633

  Fly   593 ALLRAKLLAGNSNSAHCLPGSTASPAPQEQSGIFVIDSEASPGSNGHKPKYRKGTAFTRSSLKKS 657
            .       |..||:......|..||......|:.:..:.|.|           .||.| |:|
  Fly   634 G-------ASTSNATTITSISALSPQTPTSQGVGIAAAAAGP-----------MTAKT-STL--- 676

  Fly   658 RSCNCSSIAKGRGVHDEPSSNLCRDQESSVLPQHPQPANHPTENFFSPLRSVGSFMQHSN 717
            .|||.|....|. .::.||:...|.::.:...|.|....|..:.....|.|:.:.||..|
  Fly   677 TSCNQSHPLCGT-ANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVN 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	66/180 (37%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	82/288 (28%)
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	70/196 (36%)
		TM helix 1	228..254	CDD:320454	10/26 (38%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	16/36 (44%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	12/28 (43%)
		7tm_GPCRs	<743..816	CDD:355774
		TM helix 6	747..772	CDD:341315
		TM helix 7	784..809	CDD:341315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910