DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and srw-42

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001023799.1	Gene:	srw-42 / 3565714	WormBaseID:	WBGene00005789	Length:	382	Species:	Caenorhabditis elegans

Alignment Length:	374	Identity:	75/374 - (20%)
Similarity:	144/374 - (38%)	Gaps:	81/374 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DAKDSDSPSSELNIPYTVF-----------EVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVS 82
            |:|.....|:...:.:.||           .|::::|....|:..:.|..|:.........:::.
Worm    11 DSKFDADESNNFLVSFEVFVGKLEQYIDLASVVISVVGFFTNIFHLAVLTRKSIRNSSVFIFLIG 75

  Fly    83 LAMADL------LVGALGIPFAILASMGL------PRNLHACLFTV---SLLVVLCTISIFCLVA 132
            :|:.||      :|....|.:.:|.|:.:      ||:..|.:|.:   .|.::...:|::..|.
Worm    76 IAICDLVRMISIIVSKSPIFYRVLLSLFIDSTCFTPRSYLAMIFDLISNILEIISLDLSVWLAVF 140

  Fly   133 VSVDRYWAILYPMAYSRNVRTRTAIFIIS-MCWVAGTIVGFLPLFG--------------WHADV 182
            :::.|...|.||.    |.|..:.:...| :|.|....:...| ||              |
Worm   141 MTIFRVLVIRYPF----NKRISSLVTSKSGLCTVIPLSIIIFP-FGLLYYFQVTIRPVSIW---- 196

  Fly   183 NHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYT--HIYRVIIKQVRQIVTMNPASDLSRRS 245
            ..:.:||..: .::..:.:.:.||.::..|......|  |:..|:.|.:..||       |...:
Worm   197 KPSSDCLGFQ-SNFFQINYKFSATELSGVLGTDTIETMIHVDGVLFKLIPSIV-------LLVAT 253

  Fly   246 SAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKA-TQNLSIIVLF-FMICWIP---LYTINCIKAF 305
            |..|.::..     |..|    :.|.|.:..|. |..|...|.| |:|..:|   .|.|....|.
Worm   254 SVLVFEIRK-----HKKT----IWAQRNKSNKDWTTKLVFFVTFTFLIAIVPQGIAYIIMFKMAE 309

  Fly   306 CPDCYV----HPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLL 350
            .|...:    .|.:..|   ||.:|..::.:::.:...::|...|::.|
Worm   310 IPILRIIAMSLPSVFSF---LSVVNGTIHFLIFYFMSSEYRMTAKHMCL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	37/199 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	65/316 (21%)
srw-42	NP_001023799.1	TM helix 1	37..61	CDD:320109	4/23 (17%)
		7TM_GPCR_Srw	40..357	CDD:370978	70/345 (20%)
		TM helix 2	70..100	CDD:320109	5/29 (17%)
		TM helix 3	121..143	CDD:320109	3/21 (14%)
		TM helix 4	164..180	CDD:320109	4/16 (25%)
		TM helix 5	231..254	CDD:320109	7/29 (24%)
		TM helix 6	277..302	CDD:320109	7/24 (29%)
		TM helix 7	318..343	CDD:320109	5/27 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910