| Sequence 1: | NP_651772.1 | Gene: | AdoR / 43583 | FlyBaseID: | FBgn0039747 | Length: | 774 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000859.2 | Gene: | HTR2C / 3358 | HGNCID: | 5295 | Length: | 458 | Species: | Homo sapiens |
| Alignment Length: | 337 | Identity: | 102/337 - (30%) |
|---|---|---|---|
| Similarity: | 163/337 - (48%) | Gaps: | 50/337 - (14%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 49 VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASM-----GLPRN 108
Fly 109 LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSR-NVRTRTAIFIISMCWVAGTIVGF 172
Fly 173 -LPLFGWHADVNHNQECLFVE-----VMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQ 231
Fly 232 IV---TMNPASDLS-------RRSSAAVVQVTTPGRGGHT-----------GTMLRVLGAARKRD 275
Fly 276 VKATQNLSIIVLFFMICWIPLYTINCIKAFC-PDC--YVHPKLTLFCIILSHLNSAVNPVLYAYH 337
Fly 338 LKDFRAALKNLL 349 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| AdoR | NP_651772.1 | 7tm_4 | 52..>220 | CDD:304433 | 66/179 (37%) |
| 7tm_1 | 58..334 | CDD:278431 | 93/311 (30%) | ||
| HTR2C | NP_000859.2 | 7tmA_5-HT2C | 54..385 | CDD:341346 | 102/337 (30%) |
| TM helix 1 | 56..80 | CDD:341346 | 8/18 (44%) | ||
| TM helix 2 | 89..111 | CDD:341346 | 12/21 (57%) | ||
| TM helix 3 | 128..150 | CDD:341346 | 8/21 (38%) | ||
| Agonist binding. /evidence=ECO:0000250 | 134..139 | 1/4 (25%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 151..153 | 1/1 (100%) | |||
| TM helix 4 | 173..189 | CDD:341346 | 3/15 (20%) | ||
| TM helix 5 | 212..235 | CDD:341346 | 4/22 (18%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 274..301 | 4/31 (13%) | |||
| TM helix 6 | 310..332 | CDD:341346 | 6/21 (29%) | ||
| Agonist binding. /evidence=ECO:0000250 | 324..328 | 2/3 (67%) | |||
| TM helix 7 | 347..372 | CDD:341346 | 6/24 (25%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 364..368 | 2/3 (67%) | |||
| PDZ-binding | 456..458 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||