DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and HTR2B

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_000858.3	Gene:	HTR2B / 3357	HGNCID:	5294	Length:	481	Species:	Homo sapiens

Alignment Length:	415	Identity:	104/415 - (25%)
Similarity:	172/415 - (41%)	Gaps:	75/415 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASM---GLPRNLH 110
            ::|.|.:|.||.|||:....|:||:..|||:::|||:||||||...:|.|:|..|   ..|..|.
Human    62 LMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLV 126

  Fly   111 ACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGF-LP 174
            .|...:.|.|:..|.||..|.|:|||||.||..|:..::.....||...|::.|:....:.. :|
Human   127 LCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVP 191

  Fly   175 LFGWHADVN--HNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNP 237
            :.|...||:  :|..|:..:....::::|...|...||..:|:..|......:.|:. .:|...|
Human   192 IKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKA-YLVKNKP 255

  Fly   238 ASDLSRRSSAAVVQ---------------------VTTPGRGGHTGTMLRVLGAARKRDVKATQN 281
            ...|:..:.:.|.|                     ...|..|..  |::|......|:.|:...|
Human   256 PQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDE--TLMRRTSTIGKKSVQTISN 318

  Fly   282 -------LSIIVLFFMICWIPLYTINCIKAFCPDC---YVHPKLTLFCIILSHLNSAVNPVLYAY 336
                   |.|:...|::.|.|.:..|.....|..|   .:...|.:| :.:.:::|.|||::|..
Human   319 EQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIF-VWIGYVSSGVNPLVYTL 382

  Fly   337 HLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQ 401
            ..|.||                   :|..|: :...:|.......:|....::|.
Human   383 FNKTFR-------------------DAFGRY-ITCNYRATKSVKTLRKRSSKIYF---------- 417

  Fly   402 QQEALKNSQLLPKCGVVSPCFNNIN 426
            :....:||:...|.|:    .|.||
Human   418 RNPMAENSKFFKKHGI----RNGIN 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	60/173 (35%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	85/312 (27%)
HTR2B	NP_000858.3	7tm_1	71..380	CDD:278431	85/312 (27%)
		7tm_4	72..>188	CDD:304433	45/115 (39%)
		Agonist binding. /evidence=ECO:0000269\|PubMed:23519215, ECO:0000269\|PubMed:24357322, ECO:0000269\|PubMed:28129538, ECO:0007744\|PDB:4IB4, ECO:0007744\|PDB:4NC3, ECO:0007744\|PDB:5TVN	135..140		1/4 (25%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000305\|PubMed:23519215, ECO:0000305\|PubMed:28129538	152..154		1/1 (100%)
		[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000305\|PubMed:23519215, ECO:0000305\|PubMed:28129538	212..215		0/2 (0%)
		Agonist binding. /evidence=ECO:0000269\|PubMed:23519215, ECO:0000269\|PubMed:24357322, ECO:0000269\|PubMed:28129538, ECO:0007744\|PDB:4IB4, ECO:0007744\|PDB:4NC3, ECO:0007744\|PDB:5TVN	337..341		2/3 (67%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000305\|PubMed:23519215, ECO:0000305\|PubMed:28129538	376..380		2/3 (67%)
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11150294	479..481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910