| Sequence 1: | NP_651772.1 | Gene: | AdoR / 43583 | FlyBaseID: | FBgn0039747 | Length: | 774 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000854.1 | Gene: | HTR1B / 3351 | HGNCID: | 5287 | Length: | 390 | Species: | Homo sapiens |
| Alignment Length: | 385 | Identity: | 109/385 - (28%) |
|---|---|---|---|
| Similarity: | 174/385 - (45%) | Gaps: | 62/385 - (16%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 17 PLLPLHAATTSKDAKDSDSPS-----------SELNIPYTVFEV----LVAIVSIIGNVLVIIVF 66
Fly 67 RRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLH--ACLFTVSLLVVLCTISIFC 129
Fly 130 LVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHN-QECLFVEV 193
Fly 194 MDYNYLVFLYFATI---ITPALLMLAFYTHIY----RVIIKQV----------RQIVTMNPASDL 241
Fly 242 SRRSSAAVVQVTTPGRGGHTGTMLRV----------------LGAARKRDVKATQNLSIIVLFFM 290
Fly 291 ICWIPLYTINCIKAFCPD-CYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| AdoR | NP_651772.1 | 7tm_4 | 52..>220 | CDD:304433 | 52/173 (30%) |
| 7tm_1 | 58..334 | CDD:278431 | 93/312 (30%) | ||
| HTR1B | NP_000854.1 | 7tmA_5-HT1B_1D | 46..380 | CDD:320455 | 100/343 (29%) |
| TM helix 1 | 51..77 | CDD:320455 | 5/25 (20%) | ||
| TM helix 2 | 84..110 | CDD:320455 | 12/25 (48%) | ||
| TM helix 3 | 122..152 | CDD:320455 | 13/29 (45%) | ||
| Agonist binding | 125..134 | 1/8 (13%) | |||
| DRY motif, important for ligand-induced conformation changes and signaling | 146..148 | 1/1 (100%) | |||
| TM helix 4 | 164..187 | CDD:320455 | 5/22 (23%) | ||
| TM helix 5 | 205..234 | CDD:320455 | 8/28 (29%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 259..281 | 5/25 (20%) | |||
| TM helix 6 | 307..337 | CDD:320455 | 14/31 (45%) | ||
| Agonist binding | 327..331 | 2/3 (67%) | |||
| TM helix 7 | 348..373 | CDD:320455 | 8/24 (33%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling | 365..369 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||