| Sequence 1: | NP_651772.1 | Gene: | AdoR / 43583 | FlyBaseID: | FBgn0039747 | Length: | 774 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_058950.1 | Gene: | Htr2a / 29595 | RGDID: | 61800 | Length: | 471 | Species: | Rattus norvegicus |
| Alignment Length: | 484 | Identity: | 128/484 - (26%) |
|---|---|---|---|
| Similarity: | 213/484 - (44%) | Gaps: | 101/484 - (20%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 15 EGPLLPLHAATTSKDAKDSDSP------------SSELNIPYTVFEVL--------------VAI 53
Fly 54 VSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASM-----GLPRNLHACL 113
Fly 114 FTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSR-NVRTRTAIFIISMCWVAGTIVGFLPLFG 177
Fly 178 WHAD--VNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASD 240
Fly 241 LSRR--------------SSAAVVQVT---TPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLF 288
Fly 289 FMICWIPLYTINCIKAFCPD-C---YVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
Fly 350 LKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPK 414
Fly 415 CGVVS--------PCFNNI---NQTVAAV 432 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| AdoR | NP_651772.1 | 7tm_4 | 52..>220 | CDD:304433 | 61/175 (35%) |
| 7tm_1 | 58..334 | CDD:278431 | 93/304 (31%) | ||
| Htr2a | NP_058950.1 | 7tmA_5-HT2A | 75..391 | CDD:341345 | 99/331 (30%) |
| TM helix 1 | 77..101 | CDD:341345 | 8/23 (35%) | ||
| TM helix 2 | 110..132 | CDD:341345 | 11/21 (52%) | ||
| TM helix 3 | 149..171 | CDD:341345 | 7/21 (33%) | ||
| Agonist binding. /evidence=ECO:0000250|UniProtKB:P41595 | 155..160 | 1/4 (25%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 | 172..174 | 1/1 (100%) | |||
| TM helix 4 | 194..210 | CDD:341345 | 3/15 (20%) | ||
| TM helix 5 | 232..255 | CDD:341345 | 4/26 (15%) | ||
| TM helix 6 | 322..344 | CDD:341345 | 5/21 (24%) | ||
| Agonist binding. /evidence=ECO:0000250|UniProtKB:P41595 | 336..340 | 2/3 (67%) | |||
| TM helix 7 | 359..384 | CDD:341345 | 9/25 (36%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 | 376..380 | 2/3 (67%) | |||
| PDZ-binding. /evidence=ECO:0000250|UniProtKB:P28223 | 469..471 | 0/1 (0%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.910 | |||||