DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Taar7e

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_783180.2	Gene:	Taar7e / 294133	RGDID:	631394	Length:	358	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	97/378 - (25%)
Similarity:	161/378 - (42%)	Gaps:	92/378 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYI 80
            ||.|.|||                      ||. ..|::::.||:||:......|:|....|:.:
  Rat    45 GPRLILHA----------------------VFG-FSAVLAVCGNLLVMTSILHFRQLHSPANFLV 86

  Fly    81 VSLAMADLLVGALGIPFAILASM------GLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYW 139
            .|||.||||||...:||:::.|:      |   ::: |.|..|..|..|..|:|.|..:|||||.
  Rat    87 ASLACADLLVGLTVMPFSMVRSVEGCWYFG---DIY-CKFHSSFDVSFCYCSLFHLCFISVDRYI 147

  Fly   140 AILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVN-----------------HNQE 187
            |:..|:.|........:...|:..|....|..|..|:...::..                 .||.
  Rat   148 AVSDPLIYPTRFTASVSGKCITFSWFLSIIYSFSLLYTGASEAGLEDLVSALTCVGGCQLAVNQS 212

  Fly   188 CLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQV 252
            .:|:     |:|:||      .|.|:|:..|:.::.:..:|.:.|..:  ....:|.|.:...:|
  Rat   213 WVFI-----NFLLFL------VPTLVMMTVYSKVFLIAKQQAQNIEKI--GKQTARASESYKDRV 264

  Fly   253 TTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKA---FCPDCYVHPK 314
            .                   ||:.||.:.|.|.|..|::.|:|.:..:.|.|   |....||:..
  Rat   265 A-------------------KRERKAAKTLGITVAAFLLSWLPYFIDSIIDAFLGFITPTYVYEI 310

  Fly   315 LTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRF 367
            |    :.:::.|||:||::||:....||.|:|   |.:.|..:.:.:.|.:.|
  Rat   311 L----VWIAYYNSAMNPLIYAFFYPWFRKAIK---LIVTGKILRENSSATNLF 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	53/190 (28%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	78/301 (26%)
Taar7e	NP_783180.2	7tm_GPCRs	49..337	CDD:421689	88/350 (25%)
		TM helix 1	49..75	CDD:410628	10/48 (21%)
		TM helix 2	82..108	CDD:410628	12/25 (48%)
		TM helix 3	120..150	CDD:410628	14/29 (48%)
		TM helix 4	162..185	CDD:410628	5/22 (23%)
		TM helix 5	209..238	CDD:410628	11/39 (28%)
		TM helix 6	266..296	CDD:410628	10/29 (34%)
		TM helix 7	305..330	CDD:410628	10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910