DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Taar7b

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_783176.2	Gene:	Taar7b / 294126	RGDID:	631392	Length:	358	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	100/362 - (27%)
Similarity:	159/362 - (43%)	Gaps:	77/362 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAI 99
            ||...| |.|.||. ..|::::.||:||:......|:|....|:.:.|||.||.|||...:||::
  Rat    43 SPGPRL-ILYAVFG-FGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSM 105

  Fly   100 LASM------GLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIF 158
            :.|:      |   ::: |.|..|.....|..|||.|..:|.|||.|:..|:.|........:..
  Rat   106 VRSVEGCWYFG---DIY-CKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGK 166

  Fly   159 IISMCWVAGTIVGFLPLFGWHADVNH--------------------NQECLFVEVMDYNYLVFLY 203
            .|:..|:...|..| .||  :..||.                    ||..:|:     |:|:||
  Rat   167 CITFSWLLSIIYSF-SLF--YTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFI-----NFLLFL- 222

  Fly   204 FATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVL 268
                 .|||:|:..|:.|:.:..:|.:.|..|  ....:|.|.:...:|.
  Rat   223 -----VPALVMMTVYSKIFLIAKQQAQNIEKM--GKQTARASESYKDRVA--------------- 265

  Fly   269 GAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKA---FCPDCYVHPKLTLFCIILSHLNSAVN 330
                ||:.||.:.|.|.|..|::.|:|.:..:.|.|   |....||:..|    :.:.:.|||:|
  Rat   266 ----KRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEIL----VWIGYYNSAMN 322

  Fly   331 PVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRF 367
            |::||:....||.|:|   |.:.|..:.:.:.|.:.|
  Rat   323 PLIYAFFYPWFRKAIK---LIVTGKILRENSSATNLF 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	55/193 (28%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	82/304 (27%)
Taar7b	NP_783176.2	7tm_GPCRs	49..337	CDD:421689	91/331 (27%)
		TM helix 1	49..75	CDD:410628	9/26 (35%)
		TM helix 2	82..108	CDD:410628	11/25 (44%)
		TM helix 3	120..150	CDD:410628	13/29 (45%)
		TM helix 4	162..185	CDD:410628	6/25 (24%)
		TM helix 5	209..238	CDD:410628	13/39 (33%)
		TM helix 6	266..296	CDD:410628	10/29 (34%)
		TM helix 7	305..330	CDD:410628	10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910