DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Adra1a

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_058887.2	Gene:	Adra1a / 29412	RGDID:	2055	Length:	466	Species:	Rattus norvegicus

Alignment Length:	382	Identity:	105/382 - (27%)
Similarity:	182/382 - (47%)	Gaps:	48/382 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SKDAKDSDS---PSSELNIPYTVFEVLV----AIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLA 84
            |::|.:..:   |.:.:||...:...::    .|..::||:|||:.....|.|...|:||||:||
  Rat     5 SENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLA 69

  Fly    85 MADLLVGALGIPFA----ILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPM 145
            :||||:.:..:||:    ||......|..  |....::.|:.||.||..|..:|:|||..:.||:
  Rat    70 VADLLLTSTVLPFSAIFEILGYWAFGRVF--CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPL 132

  Fly   146 AYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQE-CLFVEVMDYNYLVFLYFATIIT 209
            .|...|..|..:..:...||...::...|||||......::. |...|  :..|::|....:...
  Rat   133 RYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINE--EPGYVLFSALGSFYV 195

  Fly   210 PALLMLAFYTHIYRVIIKQVRQIVT--MNPASDLSRRSSAAVVQVTTPGRGG-------HTGTML 265
            |..::|..|..:|.|..::.|.:.:  ....|| |.:.:..:.:...|..||       .|...:
  Rat   196 PLAIILVMYCRVYVVAKRESRGLKSGLKTDKSD-SEQVTLRIHRKNVPAEGGGVSSAKNKTHFSV 259

  Fly   266 RVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCII--LSHLNSA 328
            |:|..:|::  ||.:.|.|:|..|::||:|.:.:..|.:|.||  ..|..|:|.|:  |.:|||.
  Rat   260 RLLKFSREK--KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD--FKPSETVFKIVFWLGYLNSC 320

  Fly   329 VNPVLYAYHLKDFRAALKNLL-----------LKMMGVDIDQQAEAIHRFSVASQHR 374
            :||::|....::|:.|.:|:|           ...:|..:...::|:.     .|||
  Rat   321 INPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALE-----GQHR 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	54/172 (31%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	89/291 (31%)
Adra1a	NP_058887.2	7tmA_alpha1A_AR	27..337	CDD:320448	92/318 (29%)
		TM helix 1	29..53	CDD:320448	6/23 (26%)
		TM helix 2	62..84	CDD:320448	12/21 (57%)
		TM helix 3	100..122	CDD:320448	6/21 (29%)
		TM helix 4	145..161	CDD:320448	2/15 (13%)
		TM helix 5	182..205	CDD:320448	4/22 (18%)
		TM helix 6	271..293	CDD:320448	7/21 (33%)
		TM helix 7	305..330	CDD:320448	10/24 (42%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		3/14 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910