DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Adora2b

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_058857.2	Gene:	Adora2b / 29316	RGDID:	2050	Length:	332	Species:	Rattus norvegicus

Alignment Length:	358	Identity:	117/358 - (32%)
Similarity:	176/358 - (49%)	Gaps:	67/358 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRN 108
            |...|:::|.:::.|||||.........|:..|||::||||.||:.||...|||||..|:|...:
  Rat    10 YVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTD 74

  Fly   109 LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFL 173
            .|:|||....::||...|||.|:||:||||.||..|:.|...|....|..||::.||....:|..
  Rat    75 FHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLT 139

  Fly   174 PLFGWHA------------DVNHNQ-----ECLFVEVMDYNYLV-FLYFATIITPALLMLAFYTH 220
            |..||::            |...|:     :|||..|:..:|:| |.:|..::.|.|:|:..|..
  Rat   140 PFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMSYMVYFNFFGCVLPPLLIMMVIYIK 204

  Fly   221 IYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSII 285
            |:.|..||::.:..|.                       |:.|.|       :|::.|.::|::|
  Rat   205 IFMVACKQLQHMELME-----------------------HSRTTL-------QREIHAAKSLAMI 239

  Fly   286 VLFFMICWIPLYTINCIKAFCPDCYVHPKLTL--------FCIILSHLNSAVNPVLYAYHLKDFR 342
            |..|.:||:|::.||||..|      ||.|..        ..|:|||.||.||||:|||..:|||
  Rat   240 VGIFALCWLPVHAINCITLF------HPALAKDKPKWVMNVAILLSHANSVVNPVVYAYRNRDFR 298

  Fly   343 AALKNLLLKMMGVDIDQ-----QAEAIHRFSVA 370
            .:...::.:.:....|.     ||.....||::
  Rat   299 YSFHRIISRYVLCQTDTKGGSGQAGGQSTFSLS 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	69/185 (37%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	103/301 (34%)
Adora2b	NP_058857.2	7tm_GPCRs	8..301	CDD:421689	112/326 (34%)
		TM helix 1	9..35	CDD:410628	8/24 (33%)
		TM helix 2	42..69	CDD:410628	16/26 (62%)
		TM helix 3	78..108	CDD:410628	16/29 (55%)
		TM helix 4	122..140	CDD:410628	6/17 (35%)
		Agonist binding. /evidence=ECO:0000250	173..182		2/8 (25%)
		TM helix 5	179..209	CDD:410628	9/29 (31%)
		TM helix 6	227..257	CDD:410628	12/29 (41%)
		Agonist binding. /evidence=ECO:0000250	247..254		2/6 (33%)
		Agonist binding. /evidence=ECO:0000250	266..276		0/9 (0%)
		TM helix 7	269..294	CDD:410628	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344427
Domainoid	1	1.000	174	1.000	Domainoid score	I3568
eggNOG	1	0.900	-	-		E33208_3BF5B
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000536
OrthoInspector	1	1.000	-	-		otm45013
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24246
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X919
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.800