DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Lgr4

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_775450.2	Gene:	Lgr4 / 286994	RGDID:	628615	Length:	951	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	80/398 - (20%)
Similarity:	131/398 - (32%)	Gaps:	141/398 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 HAATTSKDAKDSDSPSSELN-----------------------------IPYTVFEVLVAIVSII 57
            |:.|..|.|.|:.:.:|...                             |..||:  .:.:|:::
  Rat   492 HSVTKEKGATDAANVTSTAENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVW--FIFLVALL 554

  Fly    58 GNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGA-LGI-------------PFAILASMGLPRN 108
            .|:|||:...........:..:|..:::::||:|. .||             .|.|....|
  Rat   555 FNLLVILTVFASCSSLPASKLFIGLISVSNLLMGIYTGILTFLDAVSWGRFAEFGIWWETG---- 615

  Fly   109 LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFL 173
             ..|....||.|.....::|.|...:|:|.......|.:.::...|.......:..:...:.|..
  Rat   616 -SGCKVAGSLAVFSSESAVFLLTLAAVERSVFAKDLMKHGKSSHLRQFQVAALLALLGAAVAGCF 679

  Fly   174 PLFGWH-ADVNHNQECL------------FVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVI 225
            |||  | ...:.:..||            .|.::..|.|.|          |||...||.:|..:
  Rat   680 PLF--HGGQYSASPLCLPFPTGETPSLGFTVTLVLLNSLAF----------LLMAIIYTKLYCNL 732

  Fly   226 IKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFM 290
            .|:           |||..|.::|::        |
  Rat   733 EKE-----------DLSENSQSSVIK--------H------------------------------ 748

  Fly   291 ICWIPLYTINCIKAFCPDCYVH--PKLTLFCI----------ILSHLNSAVNPVLYAYHLKDFRA 343
            :.|: ::| ||| .|||..:..  |.:|...|          |...|.:.:|||||.:....|:.
  Rat   749 VAWL-IFT-NCI-FFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKE 810

  Fly   344 ALKNLLLK 351
            ..|  |||
  Rat   811 DWK--LLK 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	39/194 (20%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	63/314 (20%)
Lgr4	NP_775450.2	LRRNT	29..61	CDD:214470
		LRR 1	58..79
		leucine-rich repeat	59..82	CDD:275380
		LRR	<62..301	CDD:227223
		LRR 2	82..103
		leucine-rich repeat	83..106	CDD:275380
		LRR 3	106..127
		leucine-rich repeat	107..130	CDD:275380
		LRR 4	130..151
		leucine-rich repeat	131..154	CDD:275380
		LRR 5	154..177
		leucine-rich repeat	155..178	CDD:275380
		LRR 6	178..199
		leucine-rich repeat	179..202	CDD:275380
		LRR 7	202..223
		leucine-rich repeat	203..226	CDD:275380
		LRR 8	226..247
		leucine-rich repeat	227..249	CDD:275380
		LRR 9	249..270
		leucine-rich repeat	250..273	CDD:275380
		LRR 10	273..294
		leucine-rich repeat	274..295	CDD:275380
		LRR	275..>465	CDD:227223
		LRR 11	320..341
		leucine-rich repeat	321..344	CDD:275378
		LRR 12	344..365
		LRR_8	345..401	CDD:404697
		leucine-rich repeat	345..366	CDD:275378
		LRR 13	366..387
		leucine-rich repeat	367..390	CDD:275378
		LRR 14	390..411
		leucine-rich repeat	391..414	CDD:275378
		LRR 15	414..435
		leucine-rich repeat	415..427	CDD:275378
		leucine-rich repeat	436..461	CDD:275380
		7tmA_LGR4	539..812	CDD:320483	70/343 (20%)
		TM helix 1	541..565	CDD:320483	8/25 (32%)
		TM helix 2	574..595	CDD:320483	6/20 (30%)
		TM helix 3	619..641	CDD:320483	5/21 (24%)
		TM helix 4	664..680	CDD:320483	1/15 (7%)
		TM helix 5	704..727	CDD:320483	8/32 (25%)
		TM helix 6	746..768	CDD:320483	9/62 (15%)
		TM helix 7	780..805	CDD:320483	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910