DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and GPR34

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001091048.1	Gene:	GPR34 / 2857	HGNCID:	4490	Length:	381	Species:	Homo sapiens

Alignment Length:	432	Identity:	97/432 - (22%)
Similarity:	169/432 - (39%)	Gaps:	117/432 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAFRYFSITDFSFEGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVF 66
            |:.|...||:.|.:.|.........:....|....|:.|...|:|    :.||.::||::.:.||
Human    19 SSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSV----IFIVGLVGNIIALYVF 79

  Fly    67 RRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLHACLFTVSLLVVLCT------- 124
            ....:.|.....|::::|:||||: ...:||.|:        .|......:|.|:||.
Human    80 LGIHRKRNSIQIYLLNVAIADLLL-IFCLPFRIM--------YHINQNKWTLGVILCKVVGTLFY 135

  Fly   125 ----ISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLF------GWH 179
                |||..|..:|:|||..|...:...:.:.|:.:|::..:.|:. .:.|||.:.      |.|
Human   136 MNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWML-ALGGFLTMIILTLKKGGH 199

  Fly   180 ADV-------NHNQ--ECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTM 235
            ...       .||.  |.:|      |:::.:.|..|.   ||::..|..|.:.:::
Human   200 NSTMCFHYRDKHNAKGEAIF------NFILVVMFWLIF---LLIILSYIKIGKNLLR-------- 247

  Fly   236 NPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTIN 300
                 :|:|.|      ..|..|.:..|               .:|..|:::.|.||::|.:...
Human   248 -----ISKRRS------KFPNSGKYATT---------------ARNSFIVLIIFTICFVPYHAFR 286

  Fly   301 CI----KAFCPDCY----VHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDI 357
            .|    :.....||    || |.....::||..||.::||:|.....:.|..:..||.:..
Human   287 FIYISSQLNVSSCYWKEIVH-KTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRF---- 346

  Fly   358 DQQAE--------------AIHRFSVASQHRLQSMDSNMRST 385
              |.|              ::|..|||.:     :.|:.:||
Human   347 --QGEPSRSESTSEFKPGYSLHDTSVAVK-----IQSSSKST 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	48/193 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	71/309 (23%)
GPR34	NP_001091048.1	7tmA_GPR34-like	55..338	CDD:320276	78/340 (23%)
		TM helix 1	57..81	CDD:320276	9/27 (33%)
		TM helix 2	90..111	CDD:320276	8/21 (38%)
		TM helix 3	128..150	CDD:320276	4/21 (19%)
		TM helix 4	173..189	CDD:320276	4/16 (25%)
		TM helix 5	216..239	CDD:320276	7/31 (23%)
		TM helix 6	265..287	CDD:320276	6/21 (29%)
		TM helix 7	306..331	CDD:320276	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910