DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and GPR27

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_061844.1	Gene:	GPR27 / 2850	HGNCID:	4482	Length:	375	Species:	Homo sapiens

Alignment Length:	371	Identity:	82/371 - (22%)
Similarity:	129/371 - (34%)	Gaps:	72/371 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADL 88
            |..|:........::.|.:......:|:. ||:.||||..::..|||.|.|...|.::.|.:||.
Human     2 ANASEPGGSGGGEAAALGLKLATLSLLLC-VSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADG 65

  Fly    89 LVGALGIPFAIL------ASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAY 147
            |.....:|..:|      |:.|.|.....|.....|..:.|..:.|.|:.|.|.||.||.:...|
Human    66 LRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFY 130

  Fly   148 S-RNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMD--YNYLVFLYFATIIT 209
            : |......|..::...|.......|.|:.....| :.:..|...:..|  ...|.||....::.
Human   131 AERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGD-DEDAPCALEQRPDGAPGALGFLLLLAVVV 194

  Fly   210 PA----LLMLAFYTHIYRVIIKQVRQIVTMNPA-------SDLSRRSSAAVVQVTT--------- 254
            .|    .|.|.|:.|..|          .|.||       .|.:.....|..|...
Human   195 GATHLVYLRLLFFIHDRR----------KMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRG 249

  Fly   255 -------------PGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAF- 305
                         ||||.....:|...    |.:.:..:....:.|.|::.|.|....:.::..
Human   250 PTPPALVGIRPAGPGRGARRLLVLEEF----KTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLV 310

  Fly   306 ----CPDCYVHPKLTLFCIILSHLNSAVNPV---LYAYHLKD-FRA 343
                .|..|:...     :.|:...:.:|||   |:...|:| |||
Human   311 RPGAVPQAYLTAS-----VWLTFAQAGINPVVCFLFNRELRDCFRA 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	48/180 (27%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	70/325 (22%)
GPR27	NP_061844.1	7tmA_SREB1_GPR27	19..349	CDD:320344	76/350 (22%)
		TM helix 1	21..45	CDD:320344	7/24 (29%)
		TM helix 2	54..76	CDD:320344	6/21 (29%)
		TM helix 3	96..118	CDD:320344	5/21 (24%)
		TM helix 4	142..158	CDD:320344	2/15 (13%)
		TM helix 5	181..204	CDD:320344	5/22 (23%)
		TM helix 6	283..305	CDD:320344	4/21 (19%)
		TM helix 7	317..342	CDD:320344	6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910