DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and GNRHR

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_000397.1	Gene:	GNRHR / 2798	HGNCID:	4421	Length:	328	Species:	Homo sapiens

Alignment Length:	365	Identity:	66/365 - (18%)
Similarity:	130/365 - (35%)	Gaps:	98/365 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVF----------------------RRE 69
            |...:.:.:..|.:|....:.:..:..:::.|.:.|.:.|                      ::|
Human     4 SASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKE 68

  Fly    70 R-KLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLHACLFTVSLLV-VLCTISI----- 127
            : |...|....:..|.:|:||...:.:|   |..|.   |:....:...||. ||..:.:
Human    69 KGKKLSRMKLLLKHLTLANLLETLIVMP---LDGMW---NITVQWYAGELLCKVLSYLKLFSMYA 127

  Fly   128 --FCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGW---HADVNHNQE 187
              |.:|.:|:||..||..|:|...|  ::....::.:.|:..::.....|:.:   |...:..|.
Human   128 PAFMMVVISLDRSLAITRPLALKSN--SKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQT 190

  Fly   188 CLFVEVMD------------YNYLVFLYFATIITPALLMLAFYTHIY----RVIIKQVRQIVTMN 236
            .:|.:.:.            ||:  |.:....|.|..:||.....|.    ||:.:...::....
Human   191 KVFSQCVTHCSFSQWWHQAFYNF--FTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQ 253

  Fly   237 PASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLF---FMICWIPLYT 298
            ..:::.|                           ||.:.:|.|      |.|   |.:||.|.|.
Human   254 SKNNIPR---------------------------ARLKTLKMT------VAFATSFTVCWTPYYV 285

  Fly   299 INCIKAFCPDCY--VHPKLTLFCIILSHLNSAVNPVLYAY 336
            :.....|.|:..  :...:..|..:.:.||...:|::|.|
Human   286 LGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGY 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/213 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	61/330 (18%)
GNRHR	NP_000397.1	7tm_GPCRs	36..328	CDD:333717	62/333 (19%)
		TM helix 1	38..67	CDD:320095	2/28 (7%)
		TM helix 2	77..100	CDD:320095	6/25 (24%)
		TM helix 3	115..137	CDD:320095	4/21 (19%)
		TM helix 4	158..174	CDD:320095	1/15 (7%)
		TM helix 5	209..232	CDD:320095	7/24 (29%)
		TM helix 6	263..288	CDD:320095	9/30 (30%)
		TM helix 7	302..327	CDD:320095	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910