DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Gpr3

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_714949.2	Gene:	Gpr3 / 266769	RGDID:	628686	Length:	329	Species:	Rattus norvegicus

Alignment Length:	327	Identity:	89/327 - (27%)
Similarity:	142/327 - (43%)	Gaps:	56/327 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 AKDSDSPSSELNIPYTVFEVLVAIVSII---GNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVG 91
            |::...|::.|..| ..::|::.|...:   .|.||:.:.......|......:.|||:||||.|
  Rat    26 AEEPTGPATLLPSP-RAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAG 89

  Fly    92 -ALGIPFAILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMA-YSRNVRTR 154
             .|.:.||....:|.|   ...|..|.:|....|.||..|:|::||||.::...:. ||....||
  Rat    90 LGLVLHFAADFCIGSP---EMSLVLVGVLATAFTASIGSLLAITVDRYLSLYNALTYYSETTVTR 151

  Fly   155 TAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLV------FLYFATIITPALL 213
            |.: ::::.||....:|.:|:..|:.. :....|..|..:..|:||      |:.|.       :
  Rat   152 TYV-MLALVWVGALGLGLVPVLAWNCR-DGLTTCGVVYPLSKNHLVVLAIVFFMVFG-------I 207

  Fly   214 MLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKA 278
            ||..|..|.|::.:..:||.       |.|....|...|.|  |.| ..|:..||||
  Rat   208 MLQLYAQICRIVCRHAQQIA-------LQRHLLPASHYVAT--RKG-IATLAVVLGA-------- 254

  Fly   279 TQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRA 343
                      |..||:| :|:.|:..   |....|..|...::.:..||.:|||:||:..:|.:.
  Rat   255 ----------FAACWLP-FTVYCLLG---DANSPPLYTYLTLLPATYNSMINPVIYAFRNQDVQK 305

  Fly   344 AL 345
            .|
  Rat   306 VL 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	50/178 (28%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	79/283 (28%)
Gpr3	NP_714949.2	7tmA_GPR3	40..307	CDD:320629	84/310 (27%)
		TM helix 1	42..66	CDD:320629	5/23 (22%)
		TM helix 2	75..96	CDD:320629	9/20 (45%)
		TM helix 3	109..131	CDD:320629	8/21 (38%)
		TM helix 4	154..170	CDD:320629	3/16 (19%)
		TM helix 5	190..213	CDD:320629	7/29 (24%)
		TM helix 6	245..267	CDD:320629	10/40 (25%)
		TM helix 7	275..300	CDD:320629	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910