DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and adra2c

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_997522.1	Gene:	adra2c / 266752	ZFINID:	ZDB-GENE-021010-3	Length:	432	Species:	Danio rerio

Alignment Length:	445	Identity:	105/445 - (23%)
Similarity:	175/445 - (39%)	Gaps:	131/445 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FSITDFSFEGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVS------IIGNVLVIIV 65
            ::.|||            |.|.::.:|.|.|     |.|:.. |..:||      |:|||||:|.
Zfish    13 YTDTDF------------TPSGNSTNSTSYS-----PATIIG-LAGLVSFLILFTIVGNVLVVIA 59

  Fly    66 FRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLHA--------CLFTVSLLVVL 122
            ....|.|:...|.::||||.||:||..|.|||:      |...|..        |...::|.|:.
Zfish    60 VLTSRALKPPQNLFLVSLASADILVATLIIPFS------LANELMGYWFFGEVWCNIYLALDVLF 118

  Fly   123 CTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQE 187
            ||.||..|.|:|:||||::...:.|:.....|....:|.:.|:...::.|.||..  .|.|...|
Zfish   119 CTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKGMIVVVWLISAVISFPPLIS--MDRNTVDE 181

  Fly   188 ----CLFVEVMDYN-YLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQI--------------- 232
                |   ::.|:. |:::....:...|.::|:..|..||:|...:.|.:
Zfish   182 RRPMC---QLNDHTWYILYSSIGSFFAPCVIMILVYIRIYQVAKTRTRNMSEKRRDPDGGSGTPR 243

  Fly   233 --------------------------VTMNPASDL--------------------------SRRS 245
                                      ...||.:||                          ||::
Zfish   244 LENGLSREDSRRENGHCSSSPGERKPAEDNPDADLEDSSSSDEKAKRSQNETAPSKKDRRSSRKN 308

  Fly   246 SAAVVQVTTPGRGGHTGTMLRVLGAARK-------------RDVKATQNLSIIVLFFMICWIPLY 297
            |::....:...|.  :...|.:..:.||             |:.:.|..|::::..|::||.|.:
Zfish   309 SSSSKHSSRKSRA--SSKSLDLFSSRRKRRNTISRKKISQAREKRFTFVLAVVMGVFVVCWFPFF 371

  Fly   298 TINCIKAFCPD-CYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLK 351
            ....:...|.: |.:...|..|...:.:.||::|||:|....:|||.|.:.:|.|
Zfish   372 FSYSLYGICREPCAIPDPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRAFQKILCK 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	56/186 (30%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	84/369 (23%)
adra2c	NP_997522.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/26 (19%)
		7tm_4	44..>233	CDD:304433	58/199 (29%)
		7tm_1	52..409	CDD:278431	84/369 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..342		12/119 (10%)
		DUF1777	224..>301	CDD:285811	5/76 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910