DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Lhcgr

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_037110.1	Gene:	Lhcgr / 25477	RGDID:	3007	Length:	700	Species:	Rattus norvegicus

Alignment Length:	390	Identity:	80/390 - (20%)
Similarity:	152/390 - (38%)	Gaps:	86/390 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAFRYFSITDFSFEGPLLPLHAATTSKDAKDSD--SPSSELNIPYTVFEVLVAIVSII---GNV 60
            :|.:.|    |:.|..|       .|.:.|.:.|  :|..:: :.|....||:.:::|:   ||:
  Rat   330 LSGWDY----DYGFCSP-------KTLQCAPEPDAFNPCEDI-MGYAFLRVLIWLINILAIFGNL 382

  Fly    61 LVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASM-----GLPRNLHA--------C 112
            .|:.|....|.......:.:.:|:.||.   .:|:...::||:     |...| ||        |
  Rat   383 TVLFVLLTSRYKLTVPRFLMCNLSFADF---CMGLYLLLIASVDSQTKGQYYN-HAIDWQTGSGC 443

  Fly   113 LFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFG 177
            .......|....:|::.|..::::|:..|.|.:...:.:|.|.||.|:...|:..|::..:||.|
  Rat   444 GAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVG 508

  Fly   178 WHADVNHNQE---CLFVEV---MDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMN 236
                :::..:   ||.::|   :...|::.:....::. .:::.|.|..||         ....|
  Rat   509 ----ISNYMKVSICLPMDVESTLSQVYILSILILNVVA-FVVICACYIRIY---------FAVQN 559

  Fly   237 PASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINC 301
            |             ::|.|                 .:|.|..:.::|::.....|..|:.....
  Rat   560 P-------------ELTAP-----------------NKDTKIAKKMAILIFTDFTCMAPISFFAI 594

  Fly   302 IKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHR 366
            ..||...........:..::...:||..||.|||...|.|:.... |||...|. ..::||...|
  Rat   595 SAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFL-LLLSRFGC-CKRRAELYRR 657

Fly 367 366
Rat 658 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	39/189 (21%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	55/294 (19%)
Lhcgr	NP_037110.1	leucine-rich repeat	55..78	CDD:275380
		LRR_5	66..204	CDD:404228
		leucine-rich repeat	79..103	CDD:275380
		leucine-rich repeat	104..128	CDD:275380
		LRR 1	126..150
		leucine-rich repeat	129..150	CDD:275380
		LRR 2	152..175
		leucine-rich repeat	155..178	CDD:275380
		LRR 3	176..200
		leucine-rich repeat	179..202	CDD:275380
		LRR 4	202..224
		leucine-rich repeat	203..227	CDD:275380
		LRR 5	225..248
		leucine-rich repeat	228..248	CDD:275380
		LRR 6	250..271
		7tmA_LHCGR	365..638	CDD:320481	63/320 (20%)
		TM helix 1	366..390	CDD:320481	7/23 (30%)
		TM helix 2	399..420	CDD:320481	4/23 (17%)
		TM helix 3	444..466	CDD:320481	3/21 (14%)
		TM helix 4	489..505	CDD:320481	3/15 (20%)
		TM helix 5	529..552	CDD:320481	3/23 (13%)
		TM helix 6	572..594	CDD:320481	3/21 (14%)
		TM helix 7	606..631	CDD:320481	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910