DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and Fshr

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_954707.1	Gene:	Fshr / 25449	RGDID:	2632	Length:	692	Species:	Rattus norvegicus

Alignment Length:	397	Identity:	81/397 - (20%)
Similarity:	145/397 - (36%)	Gaps:	119/397 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TSKDAKDSDSPSSELNIPYTVFEVL---VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMAD 87
            |.....|:.:|..:: :.|.:..||   ::|::|.||..|::|....:.......:.:.:||.||
  Rat   344 TCSPKPDAFNPCEDI-MGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFLMCNLAFAD 407

  Fly    88 LLVGALGIPFAILASMGLPRNLH--------------------ACLFTVSLLVVLCTISIFCLVA 132
            |   .:||...::||:    ::|                    |..||    |....:|::.|.|
  Rat   408 L---CIGIYLLLIASV----DIHTKSQYHNYAIDWQTGAGCDAAGFFT----VFASELSVYTLTA 461

  Fly   133 VSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYN 197
            ::::|:..|.:.|.....|:.|.|..::.:.|.........|:||    ::...:......||.:
  Rat   462 ITLERWHTITHAMQLECKVQLRHAASVMVLGWTFAFAAALFPIFG----ISSYMKVSICLPMDID 522

  Fly   198 Y-LVFLYFATIITPALLMLAF------YTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTP 255
            . |..||...::  .|.:|||      |||||         :...||          .:|..::
  Rat   523 SPLSQLYVMALL--VLNVLAFVVICGCYTHIY---------LTVRNP----------TIVSSSS- 565

  Fly   256 GRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICW-------------IPLYTINCIKAFCP 307
                               |.|..:.::.::....:|.             :||.|::
  Rat   566 -------------------DTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVS------- 604

  Fly   308 DCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQ------AEAIHR 366
                  |..:..::...:||..||.|||...|:||.....||.|....::..|      :.|.|.
  Rat   605 ------KAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETSSATHN 663

  Fly   367 FSVASQH 373
            |.....|
  Rat   664 FHARKSH 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	43/194 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	59/315 (19%)
Fshr	NP_954707.1	LRRNT	23..50	CDD:214470
		LRR 1	49..72
		LRR_8	72..132	CDD:290566
		leucine-rich repeat	72..96	CDD:275380
		LRR 2	73..97
		leucine-rich repeat	97..121	CDD:275380
		LRR 3	98..118
		LRR 4	119..143
		leucine-rich repeat	122..143	CDD:275380
		leucine-rich repeat	144..171	CDD:275380
		LRR 5	144..169
		LRR 6	170..192
		leucine-rich repeat	172..194	CDD:275380
		LRR_8	193..245	CDD:290566
		LRR 7	193..216
		leucine-rich repeat	195..219	CDD:275380
		LRR 8	217..240
		leucine-rich repeat	220..243	CDD:275380
		LRR 9	241..259
		GnHR_trans	282..348	CDD:289164	1/3 (33%)
		7tm_1	378..625	CDD:278431	59/315 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910