DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and Cnr1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_036916.1	Gene:	Cnr1 / 25248	RGDID:	2369	Length:	473	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	99/367 - (26%)
Similarity:	166/367 - (45%)	Gaps:	41/367 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIV-SLAMADLLVGAL----G 94
            :||.:|.|  .|..:.:...:::.|:||:.|....|.||.|.:|:.: |||:||||...:    .
  Rat   113 NPSQQLAI--AVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSF 175

  Fly    95 IPFAILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFI 159
            :.|.:......|   :..||.:..:....|.|:..|...::|||.:|..|:||.|.|....|:..
  Rat   176 VDFHVFHRKDSP---NVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVA 237

  Fly   160 ISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRV 224
            ..:.|....::..|||.||:.....:.......::|..||:|...   :|..||:...|.::| :
  Rat   238 FCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIG---VTSVLLLFIVYAYMY-I 298

  Fly   225 IIK----QVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSII 285
            :.|    .||.|......|.:...|....||||.|.:.              :.|::..:.|.:|
  Rat   299 LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQA--------------RMDIRLAKTLVLI 349

  Fly   286 VLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLL 350
            ::..:|||.||..|.....|.....:...:..||.:|..|||.|||::||...||.|.|.:::..
  Rat   350 LVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFP 414

  Fly   351 KMMGV--DIDQ---QAEAIHRF--SVASQHRLQSMDSNMRST 385
            ...|.  .:|.   .::.:|:.  :.||.||  :.:|.::||
  Rat   415 SCEGTAQPLDNSMGDSDCLHKHANNTASMHR--AAESCIKST 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	47/172 (27%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	78/284 (27%)
Cnr1	NP_036916.1	Required for mitochondrial localization. /evidence=ECO:0000250\|UniProtKB:P47746	2..23
		7tmA_CB1	118..409	CDD:320462	86/313 (27%)
		TM helix 1	120..144	CDD:320462	6/25 (24%)
		TM helix 2	154..175	CDD:320462	8/20 (40%)
		TM helix 3	191..213	CDD:320462	5/21 (24%)
		TM helix 4	236..252	CDD:320462	1/15 (7%)
		TM helix 5	273..296	CDD:320462	8/25 (32%)
		TM helix 6	343..365	CDD:320462	8/21 (38%)
		TM helix 7	377..402	CDD:320462	11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910