DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and Htr2c

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_036897.2	Gene:	Htr2c / 25187	RGDID:	2848	Length:	460	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	107/380 - (28%)
Similarity:	172/380 - (45%)	Gaps:	57/380 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FSFEGPLLPLHAATTSKDAKDSDS------PSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRER 70
            :.|:..:.|: ||..:.....||.      |....|.| .:..|::.|::|.||:|||:....|:
  Rat    21 WQFDISISPV-AAIVTDTFNSSDGGRLFQFPDGVQNWP-ALSIVVIIIMTIGGNILVIMAVSMEK 83

  Fly    71 KLRRRTNYYIVSLAMADLLVGALGIPFAILASM-----GLPRNLHACLFTVSLLVVLCTISIFCL 130
            ||...|||:::|||:||:|||.|.:|.::||.:     .|||.|  |...:||.|:..|.||..|
  Rat    84 KLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYL--CPVWISLDVLFSTASIMHL 146

  Fly   131 VAVSVDRYWAILYPMAYSR-NVRTRTAIFIISMCWVAGTIVGF-LPLFGWHAD----VNHNQECL 189
            .|:|:|||.||..|:.:|| |.||: ||..|::.|.....|.. :|:.|...:    || |..|:
  Rat   147 CAISLDRYVAIRNPIEHSRFNSRTK-AIMKIAIVWAISIGVSVPIPVIGLRDESKVFVN-NTTCV 209

  Fly   190 FVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTT 254
               :.|.|:::...|.....|..:|:..|.....|:.:|...::..:...:|: ..|...:....
  Rat   210 ---LNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELA-NMSLNFLNCCC 270

  Fly   255 PGRGGH----------------------TGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLY 297
            ...||.                      .|||     .|...:.||::.|.|:...|:|.|.|.:
  Rat   271 KKNGGEEENAPNPNPDQKPRRKKKEKRPRGTM-----QAINNEKKASKVLGIVFFVFLIMWCPFF 330

  Fly   298 TINCIKAFCPDC---YVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            ..|.:...|...   .:..||....:.:.::.|.:||::|....|.:|.|....|
  Rat   331 ITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYL 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	67/178 (38%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	90/311 (29%)
Htr2c	NP_036897.2	7tm_4	64..>248	CDD:304433	69/190 (36%)
		7tm_1	71..370	CDD:278431	90/311 (29%)
		Agonist binding. /evidence=ECO:0000250	135..140		1/4 (25%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	152..154		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..301		0/24 (0%)
		Agonist binding. /evidence=ECO:0000250	326..330		2/3 (67%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	366..370		2/3 (67%)
		PDZ-binding	458..460
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910