DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and Htr1b

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_071561.1	Gene:	Htr1b / 25075	RGDID:	2846	Length:	386	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	111/372 - (29%)
Similarity:	166/372 - (44%)	Gaps:	51/372 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PLLPLHAATTSKDAKDSDSPSSELNIPYTVFEV----LVAIVSIIGNVLVIIVFRRERKLRRRTN 77
            ||..|....::.|....||    :.:|:.|..|    |:.:.:.:.|..||....|.|||....|
  Rat    21 PLANLSHNCSADDYIYQDS----IALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPAN 81

  Fly    78 YYIVSLAMADLLVGALGIPFAILASMGLPRNLH--ACLFTVSLLVVLCTISIFCLVAVSVDRYWA 140
            |.|.|||:.||||..|.:|.:.:.::.....|.  .|.|.:|..:..||.||..|..:::|||||
  Rat    82 YLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWA 146

  Fly   141 ILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECL--FVEVMDYNYLVFLY 203
            |...:.||.....:.|..:|.:.||....:. ||.|.|. .....:|.|  ||......|.|:..
  Rat   147 ITDAVDYSAKRTPKRAAIMIVLVWVFSISIS-LPPFFWR-QAKAEEEVLDCFVNTDHVLYTVYST 209

  Fly   204 FATIITPALLMLAFYTHIY----RVIIKQV----------RQIVTMNPASDLSRRSSAAVVQVTT 254
            ......|.||::|.|..||    ..|:||.          .|::|.:|.|    .||...:....
  Rat   210 VGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGS----TSSVTSINSRV 270

  Fly   255 PGRGGHTGTMLRV----------------LGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIK 303
            |.....:|:.:.|                |.|||:|  |||:.|.||:..|::||:|.:.|:.:.
  Rat   271 PEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARER--KATKTLGIILGAFIVCWLPFFIISLVM 333

  Fly   304 AFCPD-CYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            ..|.| |:.|..:..|...|.:|||.:||::|....:||:.|...|:
  Rat   334 PICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLI 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	55/171 (32%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	96/310 (31%)
Htr1b	NP_071561.1	7tmA_5-HT1B_1D	42..376	CDD:320455	103/341 (30%)
		TM helix 1	48..72	CDD:320455	5/23 (22%)
		TM helix 2	81..103	CDD:320455	12/21 (57%)
		TM helix 3	119..141	CDD:320455	7/21 (33%)
		Agonist binding. /evidence=ECO:0000250	121..130		1/8 (13%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	142..144		1/1 (100%)
		TM helix 4	164..180	CDD:320455	4/16 (25%)
		TM helix 5	202..225	CDD:320455	6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..276		5/24 (21%)
		TM helix 6	309..331	CDD:320455	9/21 (43%)
		Agonist binding. /evidence=ECO:0000250	323..327		2/3 (67%)
		TM helix 7	344..369	CDD:320455	8/24 (33%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	361..365		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910