DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Htr1a

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_036717.1	Gene:	Htr1a / 24473	RGDID:	2845	Length:	422	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	102/389 - (26%)
Similarity:	159/389 - (40%)	Gaps:	79/389 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SELNIPYTVFEVL----VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFA 98
            |::...|.|...|    :...:::||..|:.....||.|:...||.|.|||:.||:|..|.:|.|
  Rat    29 SDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMA 93

  Fly    99 ILASMGLPRNLH--ACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIIS 161
            .|..:.....|.  .|...::|.|:.||.||..|.|:::||||||..|:.|......|.|..:||
  Rat    94 ALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALIS 158

  Fly   162 MCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRV-- 224
            :.|:.|.::...|:.||....:.:.........|:.|.::..|.....|.||||..|..|:|.
  Rat   159 LTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAAR 223

  Fly   225 --IIKQVRQIVTMNPASDLSRRSS---------------------------------------AA 248
              |.|.||::......:.|...|:                                       .|
  Rat   224 FRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEA 288

  Fly   249 VVQVTTPGRGGHTGTML---------------------------RVLGAARKRDVKATQNLSIIV 286
            .::|....|.|::...|                           |.:..||:|  |..:.|.||:
  Rat   289 TLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARER--KTVKTLGIIM 351

  Fly   287 LFFMICWIPLYTINCIKAFC-PDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            ..|::||:|.:.:..:..|| ..|::...|......|.:.||.:|||:|||..|||:.|.|.::
  Rat   352 GTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	55/169 (33%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	90/348 (26%)
Htr1a	NP_036717.1	7tm_4	48..>169	CDD:304433	43/120 (36%)
		7tm_1	53..400	CDD:278431	90/348 (26%)
		Agonist binding. /evidence=ECO:0000250	112..121		2/8 (25%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	133..135		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..261		2/25 (8%)
		Agonist binding. /evidence=ECO:0000250	358..362		2/3 (67%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	396..400		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910