DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and fshr

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001001812.1	Gene:	fshr / 195820	ZFINID:	ZDB-GENE-020423-5	Length:	668	Species:	Danio rerio

Alignment Length:	345	Identity:	73/345 - (21%)
Similarity:	137/345 - (39%)	Gaps:	95/345 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DSDSPSSELNIPYTVFEVL---VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGAL 93
            |:.:|..:: :.:|...||   :::::|:||.:|::|....|.......:.:..||.|||   .:
Zfish   332 DAFNPCEDI-MGFTFLRVLIWFISVLAIVGNTVVLLVLLTSRYKLTVPRFLMCHLAFADL---CM 392

  Fly    94 GIPFAILASMGLPRNLH----------------ACLFTVSLLVVLCTISIFCLVAVSVDRYWAIL 142
            ||...::|::    ::|                .|.......|....:|::.|.|::::|:..|.
Zfish   393 GIYLLLIAAV----DIHTQSRYYNYGIDWQTGAGCHVAGFFTVFSSELSVYTLTAITLERWHTIT 453

  Fly   143 YPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEV---MDYNYLVFLYF 204
            |.|...|.:|.|.|..:::..|:...:...:|:|| .:..:....||.::|   :...|:|.|
Zfish   454 YAMQLERQMRLRHACLVMATGWLFSLLAALMPMFG-VSSYSKTSICLPMDVETLLSQGYVVLL-- 515

  Fly   205 ATIITPA--LLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRV 267
             .::..|  |::...||.||         :...|||              ..|...
Zfish   516 -LLLNAAAFLVVCVCYTLIY---------LTVRNPA--------------FVPANA--------- 547

  Fly   268 LGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSH-------- 324
                   |::..:.:::::....:|..|:.......||        ||.|  |..||
Zfish   548 -------DMRIAKRMAVLIFTDFLCMAPISFFAISAAF--------KLPL--ITASHAKVLLVLF 595

  Fly   325 --LNSAVNPVLYAYHLKDFR 342
              :||..||.|||:..|.|:
Zfish   596 YPINSCSNPFLYAFFTKTFK 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	41/188 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	62/306 (20%)
fshr	NP_001001812.1	leucine-rich repeat	79..103	CDD:275380
		LRR_5	93..224	CDD:290045
		leucine-rich repeat	104..127	CDD:275380
		leucine-rich repeat	128..151	CDD:275380
		leucine-rich repeat	152..177	CDD:275380
		leucine-rich repeat	180..202	CDD:275380
		leucine-rich repeat	203..227	CDD:275380
		leucine-rich repeat	228..251	CDD:275380
		leucine-rich repeat	252..274	CDD:275380
		7tm_1	360..607	CDD:278431	62/306 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910