DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Ptger3

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001346674.1	Gene:	Ptger3 / 19218	MGIID:	97795	Length:	366	Species:	Mus musculus

Alignment Length:	375	Identity:	71/375 - (18%)
Similarity:	134/375 - (35%)	Gaps:	92/375 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVF-----RRERKLRRRTNYY 79
            |.|:|....:...:......:::   .|.:.:.:...:||.|.:::.     |||.|.::.....
Mouse     7 PEHSAEAHSNLSSTTDDCGSVSV---AFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLC 68

  Fly    80 IVSLAMADLLVGALGIPFAILASMG------LPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRY 138
            |..||:.||:...|..|..||..:.      |..:...|.|....:.|....|:....|::|:|.
Mouse    69 IGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERA 133

  Fly   139 WAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFG-----------WHADVNHNQECLFVE 192
            .||..|..|:.:::||....::...|::......||:.|           |         | |:.
Mouse   134 LAIRAPHWYASHMKTRATRAVLLGVWLSVLAFALLPVLGVGRYSVQWPGTW---------C-FIS 188

  Fly   193 ----------VMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSA 247
                      ..:...:.|......:....|::.|..:     :..::.:|:...|.....:|||
Mouse   189 TGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACN-----LATIKALVSRCRAKAAVSQSSA 248

  Fly   248 AVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVH 312
            ...::||.       |.::::|               |:....:||.|| .|..:|.......|.
Mouse   249 QWGRITTE-------TAIQLMG---------------IMCVLSVCWSPL-LIMMLKMIFNQMSVE 290

  Fly   313 PKLT-----------LFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLK 351
            ...|           |..:.|:.||..::|.:|        ..|:.:||:
Mouse   291 QCKTQMGKEKECNSFLIAVRLASLNQILDPWVY--------LLLRKILLR 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/199 (20%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	63/318 (20%)
Ptger3	NP_001346674.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		3/14 (21%)
		7tm_GPCRs	26..335	CDD:333717	68/356 (19%)
		TM helix 1	28..52	CDD:320095	4/26 (15%)
		TM helix 2	66..88	CDD:320095	7/21 (33%)
		TM helix 3	108..130	CDD:320095	4/21 (19%)
		TM helix 4	153..169	CDD:320095	1/15 (7%)
		TM helix 5	204..227	CDD:320095	3/27 (11%)
		TM helix 6	255..280	CDD:320095	9/47 (19%)
		TM helix 7	302..327	CDD:320095	6/32 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910