DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and npr-9

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001361821.1	Gene:	npr-9 / 191320	WormBaseID:	WBGene00013974	Length:	431	Species:	Caenorhabditis elegans

Alignment Length:	500	Identity:	107/500 - (21%)
Similarity:	192/500 - (38%)	Gaps:	180/500 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IPYTVFEVLVAIVSIIGNVLVIIV-FRRERKLRRRTNYYIVSLAMADLLVGALGIPFAIL----A 101
            || |:|.|:: :|.::||.||:|| |.|:  :|..||..|:.||::||:...|.:||..:    .
Worm    32 IP-TIFAVII-LVGLVGNALVVIVAFGRQ--MRNSTNTLIIGLAISDLMFLLLCVPFTAVDYAAP 92

  Fly   102 SMGLPRNLHACLFTVSLLVVLCTISIFC----LVAVSVDRYWAILYPMAYSRNVRT-RTAIFIIS 161
            :...|.      :|.|::......|.:|    |..:::|||.|::||:. |..:|| |..  :|:
Worm    93 TWIFPE------WTCSMINFFQHTSAYCSVWTLTLMALDRYLAVVYPVE-SMTLRTPRNT--VIA 148

  Fly   162 MCWVAGTIVGF-LPLFGWHADVNHNQECLFVEVMDYNYLV-------FLYFATI-ITPALLMLAF 217
            :|::...|:.. :|:...|.        ::|    |::::       .|..||. .||.:....|
Worm   149 LCFIYIIIIASQIPVGRMHG--------IYV----YDFIMEKRSTCAILTIATAEATPTMARTYF 201

  Fly   218 YTH--------------IYRVIIKQV--------------RQIVTMNPASDLSRRSSAAVVQVTT 254
            .|.              :|.::::::              |.:...:..|.:.||..|
Worm   202 MTFNVFGYVLPLGISVVLYGLMLRKLWDMPRPGNSQSVGGRNLTNRDSGSSIRRRPEA------- 259

  Fly   255 PGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFC-PDCYVHPKLTLF 318
                           .|.||  |.|:.:..:::.:.:||:||.....:.... |:..|.....:.
Worm   260 ---------------TAAKR--KVTRLVLCVLITWALCWLPLNVCFFMSGLAYPEPLVISHGVIM 307

  Fly   319 CI------ILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQS 377
            .|      :|::.||.:||:|||...:.||..    .:::|.:.|::.:..  ||.
Worm   308 VIVQIASQVLAYTNSCLNPILYALMSQSFREG----FIRVMKMLINKLSRG--RFC--------- 357

  Fly   378 MDSNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPKCGVVSPCFNNINQTVAAVASVTTDLERE 442
              :|.|.:..|..:..|                               |||.|..|:
Worm   358 --TNYRRSALRTELTHY-------------------------------NQTPAHPAN-------- 381

  Fly   443 MWNIVEASSGAELGETSYEFPSPAPGSQRSS--ERNSSSTVPPAP 485
              .:|:.|:|                 :|||  :.||||.....|
Worm   382 --TVVQVSNG-----------------ERSSLLKDNSSSATSVQP 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	49/186 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	72/329 (22%)
npr-9	NP_001361821.1	7tmA_AstA_R_insect	30..340	CDD:320224	83/360 (23%)
		TM helix 1	32..56	CDD:320224	12/25 (48%)
		TM helix 2	64..86	CDD:320224	9/21 (43%)
		TM helix 3	102..124	CDD:320224	4/21 (19%)
		TM helix 4	147..163	CDD:320224	3/15 (20%)
		TM helix 5	198..221	CDD:320224	2/22 (9%)
		TM helix 6	267..289	CDD:320224	5/21 (24%)
		TM helix 7	308..333	CDD:320224	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910